New immunosuppressive therapy targeted to the intestinal macrophage for intestinal transplantation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591855
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: NIO Masaki 東北大学, 医学(系)研究科(研究院), 教授 (70228138)
• Co-Investigator(Kenkyū-buntansha): WADA Motoshi 東北大学, 医学系研究科, 准教授 (80372291)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 小腸移植 / 自然免疫 / マクロファージ / 移植免疫

Outline of Final Research Achievements

As a new target of immunosuppression therapy for intestinal transplantation, we focused on intestinal macrophages. In this study, we used flow cytometry to analyze subsets of intestinal macrophages during acute rejection. Ectopic Itx was performed in rats; the transplant groups were syngeneic and allogeneic. We defined four subsets of rat intestinal macrophages using three monoclonal antibodies. These data suggest that the ED1+ macrophages contain four subsets, with the ED2+ED3+ subset strongly correlating with AR. This subset may be a novel target of immunosuppression therapy.

Free Research Field

小腸移植