Mechanisms of abdominal aortic aneurysm formation.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SASAKI Takeshi 浜松医科大学, 技術部, 技術専門職員 (20397433)
• Co-Investigator(Kenkyū-buntansha): CHENG Xian Wu 名古屋大学, 未来社会創造機構, 准教授 (30378228) ; UNNO Naoki 浜松医科大学, 医学部, 准教授 (20291958)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 腹部大動脈瘤 / 炎症細胞 / B細胞 / カテプシン / MMP

Outline of Final Research Achievements

Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. It is suggested that inflammatory cells and proteases contribute to AAA formation. Therefore, we investigated the localization of inflammatory cells in AAA lesion. In addition, we examined the expression of proteases and their endogenous inhibitors.
Abdominal aortic tissue was harvested either from autopsy (control) or during open-repair surgery for AAA. Localization of macrophages, B cells, T cells and neutrophils were observed in AAA lesion, and significantly higher infiltration of these inflammatory cells into vascular wall of AAA was observed compared with control. More extensive immunostaining of MMPs and elastases was detected in AAA. These proteases expressed in inflammatory cells. On the other hand, expression of endogenous inhibitors against these proteases was decreased in AAA lesion.
These results suggest that inflammatory cells and some proteases may participate in AAA formation.

Free Research Field

循環器学