2013 Fiscal Year Final Research Report
The antibody therapy for RAGE ligand in organ transplantation
| Project/Area Number |
23591864
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
SADAMORI HIROSHI 岡山大学, 医歯(薬)学総合研究科, 准教授 (30362974)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Hideo 近畿大学, 医学部, 教授 (60335627)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | RAGEリガンド / 臓器移植 / 虚血再灌流障害 / 拒絶反応 / AGE / HMGB1 |
|---|
| Research Abstract |
It has been reported that advanced glycation end products (AGEs) and high mobility group box-1 (HMGB-1), which function as a receptor for AGE (RAGE) ligand, contribute to the pathogenesis of chronic inflammatory diseases, such as atherosclerosis and diabetes. In the present research, we examined the effects of RAGE ligand on the mechanism of rejection and ischemia/reperfusion injury (I/R injury) in organ transplantation. As a result, the antibody therapy for RAGE ligand can contribute to management of the rejection and improvement of I/R injury in organ transplantation.
|
