2013 Fiscal Year Final Research Report
A study for improvement of pancreatic islet transplantation outcome by using two-layer method and rare sugar
| Project/Area Number |
23591866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAGI Hirotaka 香川大学, 医学部付属病院, 病院助
ASANO Eisuke 香川大学, 医学部付属病院, 病院助
TOKUDA Masaaki 香川大学, 医学部細胞情報生理学, 教授
OKANO Keiichi 香川大学, 医学部付属病院, 準教授
HOSSAIN M・a 香川大学, 医学部, 研究員
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| Project Period (FY) |
2011 – 2013
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| Keywords | 希少糖 / 膵島移植 |
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| Research Abstract |
Islet transplantation is a curative treatment option for Type-1 diabetes. Improving islet function after isolation would result in better clinical outcomes of islet transplantation. In this study, we examined whether addition of D-allose, one of rare sugars, to islet culture medium had a beneficial effect on rat islet viability and function. As results, insulin secretion increased in the group with D-allose in overnight culture compared to the control without D-allose. In addition, diabetic nude mice transplanted islets after co-culture with D-allose demonstrated significantly higher cure rate of diabetes compared to the control. Because a oxidative stress marker (malondialdehyde) of islets was significantly reduced by co-culture with D-allose, this rare sugar possibly has an antioxidative effect.
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