Effectiveness for islet isolation by hypothermic machine perfusion presevation of pancreas

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591887
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Clinical research Center, Chiba-East National Hospital, National Hospital Organization
• Principal Investigator: AKUTSU Naotake 独立行政法人国立病院機構(千葉東病院臨床研究センター), その他部局等, その他 (00344979)
• Co-Investigator(Kenkyū-buntansha): OTSUKI Kazunori 国立病院機構千葉東病院, 臨床研究部, 室長 (50399755) ; MARUYAMA Michihiro 国立病院機構千葉東病院, 診療部長 (40399754) ; KENMOCHI Takashi 藤田保健衛生大学, 医学部臓器移植科, 教授 (50215133) ; ITO Taihei 藤田保健衛生大学, 医学部臓器移植科, 准教授 (60509701)
• Co-Investigator(Renkei-kenkyūsha): SAIGO Kenichi 国立病院機構千葉東病院, 診療部長 (60323424) ; HASEGAWA Masayuki 国立病院機構千葉東病院, 外科医長 (80648030) ; AOYAMA Hiromichi 国立病院機構千葉東病院, 外科医師 (80598243) ; MATSUMOTO Ikuko 国立病院機構千葉東病院, 外科医師 (70649128) ; NOGUCHI Hirofumi 琉球大学, 医学部再生医学講座, 教授 (50378733)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 膵島移植 / 臓器保存 / 持続冷却潅流保存

Outline of Final Research Achievements

Hypothermic machine perfusion preservation (HMP) by LifePortTM is thought to be a better preservation technique for pancreas harvested from marginal donors such as non-heart-beating donor. In this experiment, we indicated that yield and function of islet isolated from 24hours-preserved canine pancreas with LifePortTM removed after 30 minutes warm ischemic time. It suggests that HMP for pancreas would be a useful method for islet transplantation from marginal donors in Japan.

Free Research Field

移植