2013 Fiscal Year Final Research Report
Clinical appliciation of cancer treatment by revealing alternative splicing mechanism of c-myc transcriptional suppressor FBP-interacting repressor
| Project/Area Number |
23591891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOMURA Fumio 千葉大学, 大学院医学研究院, 教授 (80164739)
SATOH Mamoru 千葉大学, 医学部附属病院, 寄附研究部門教員 (20401002)
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| Project Period (FY) |
2011 – 2013
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| Keywords | がん診断 / バイオマーカー / がん治療 |
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| Research Abstract |
Recently, an interaction between FBP-interacting repressor, FIR, and TFIIH/p89/XPB helicase was found to repress c-myc transcription and so might be important for sippressing tumor formation. Further, enforced expression of FIR induced apoptosis. Deletion of FIR's amino terminal repression domain rescued the
cells from apoptosis, as did co-expression of c-Myc with FIR. Thus repression of c-myc mediates FIR-driven apoptosis. A splicing variant of FIR unable to repress c-myc nor driving apoptosis was frequently discovered in human primary colorectal cancers, but not in the adjacent normal tissues. In this study, adeno- or Sendai virus FIR expression vector was examined its anti-tumor efficacy. Additionally, FIR splicing variant was detected at their protein or mRNA level in the peripheral blood of colorectal cancer patients.
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Research Products
(17 results)
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[Journal Article] Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway2013
Author(s)
Rahmutulla B, Matsushita K, Satoh M, Seimiya M, Tsuchida S, Kubo S, Shimada H, Otsuka M, Miyazaki M, and Nomura F
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Journal Title
URL
Peer Reviewed
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[Journal Article] SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues2013
Author(s)
Kajiwara T, Matsushita K, Itoga S, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Habara Y, Matsuo M, Nomura F
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Journal Title
Cancer Sci.
Volume: 104(2)
Pages: 149-56
DOI
Peer Reviewed
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[Journal Article] Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression2013
Author(s)
Matsushita K, Tamura M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Levens D, He L, Liu J, Yoshida M, and Nomura F
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Journal Title
Mol Cancer Res.
Volume: 11(7)
Pages: 689-98
DOI
Peer Reviewed
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[Journal Article] SAP155-mediated splicing of FUSE-binding protein-interacting repressor (FIR) serves as a molecular switch for c-myc gene expression2012
Author(s)
Matsushita K, Kajiwara T, Tamura M, Satoh M, Tanaka N, Tomonaga T, Matsubara H, Shimada H, Yoshimoto R, Ito A, Kubo S, Natsume T, Levens D, Yoshida M, Nomura F
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Journal Title
Mol Cancer Res.
Volume: 10(6)
Pages: 787-99
DOI
Peer Reviewed
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[Journal Article] Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma2012
Author(s)
Nomura F, Sogawa K, Noda K, Seimiya M, Matsushita K, Miura T, Tomonaga T, Yoshitomi Hideyuki, Imazeki F, Takizawa H, Mogushi K, Miyazaki M and Yokosuka O
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Journal Title
BBRC
Volume: 421(4)
Pages: 837-43
DOI
Peer Reviewed
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[Journal Article] Proteomic analysis of gingival crevicular fluid for discovery of novel periodontal disease markers2012
Author(s)
Tsuchida S, Satoh M, Umemura H, Sogawa K, Kawashima Y, Kado S, Sawai S, Nishimura M, Kodera Y, Matsushita K, Nomura F
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Journal Title
Proteomics
Volume: 12(13)
Pages: 2190-202
DOI
Peer Reviewed
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