2013 Fiscal Year Final Research Report
Molecular mechanisms of hormone sensitivity of hormone receptor-positive breast cancer and their application for individual treatment
| Project/Area Number |
23591896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TOKUNAGA Eriko 九州大学, 医学(系)研究科(研究院), 准教授 (50325453)
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| Co-Investigator(Kenkyū-buntansha) |
KITAO Hiroyuki 九州大学, 医学研究院, 准教授 (30368617)
AKIYOSHI Sayuri 九州がんセンター臨床研究センター, その他部局等, その他 (50567360)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 乳癌 / ホルモン受容体 / ホルモン療法 |
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| Research Abstract |
To explore the molecular mechanisms of hormone sensitivity is important to improve the prognosis of hormone receptor (HR)+/HER2- breast cancer.
1) The expression of GATA-3, FOXA1 and AR was associated with good prognosis. FOXA1 is considered to be a good predictive marker of adjuvant endocrine therapy. 2) FOXA1 expression is reduced by neoadjuvant endocrine therapy, especially in tumors with low PEPI scores, suggesting FOXA1 is related to hormone sensitivity. 3) The prognosis of HR+ breast cancer with activated Akt had shorter overall survival. Akt activation is related to endocrine resistance. The better understanding of the molecular mechanisms of hormone sensitivity is necessary to improve the efficacy of endocrine therapy for breast cancer.
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[Journal Article] Molecular hierarchy of heparin-binding EGF-like growth factor- regulated angiogenesis in triple-negative breast cancer2013
Author(s)
Yotsumoto F, Tokunaga E, Oki E, Maehara Y, Yamada H, Nakajima K, Nam SO, Miyata K, Koyanagi M, Doi K, Shirasawa S, Kuroki M, Miyamoto S
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Journal Title
Mol Cancer Res
Volume: 11
Pages: 506-17
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[Journal Article] Differential impact of the expression of the androgen receptor by age in estrogen receptor–positive breast cancer2013
Author(s)
Tokunaga E, Hisamatsu Y, Taketani K, Yamashita N, Akiyoshi S, Okada S, Tanaka K, Saeki H, Oki E, Aishima S, Oda Y, Morita M, Maehara Y
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Journal Title
Cancer Med
Volume: 2
Pages: 763-773
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[Journal Article] The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer
Author(s)
Taketani K, Tokunaga E, Yamashita N, Tanaka K, Akiyoshi S, Okada S, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kusumoto T, Maehara Y
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Journal Title
Surg Today
Volume: (in press)
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[Journal Article] Impact of GATA-3 and FOXA1 expression in patients with hormone receptor-positive/ HER2-negative breast cancer
Author(s)
Hisamatsu Y, Tokunaga E, Yamashita N, Akiyoshi S, Okada S, Nakashima Y, Taketani K, Aishima S, Oda Y, Morita M, Maehara Y
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Journal Title
Breast Cancer
Volume: (in press)
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[Presentation] Different impact of the loss of heterozygosity at BRCA1 and BRCA2 loci on clinicopathological features of breast cancer2011
Author(s)
Tokunaga E, Okada S, Akiyoshi S, Yamashita N, Ando N, Saeki H, Oki E, Ohga T, Kitao H, Kakeji Y, Maehara Y
Organizer
第70回日本癌学会学術集会
Place of Presentation
名古屋
Year and Date
20111003-05
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