2012 Fiscal Year Final Research Report
Analysis of microRNAs and development of novel therapeutic strategies in breast cancer
| Project/Area Number |
23591902
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Hokkaido University (2012)
Nagoya City University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Tatsuya 名古屋市立大学, 大学院・医学研究科, 准教授 (30315882)
YOSHIMOTO Nobuyasu 名古屋市立大学, 大学院・医学研究科, 助教 (10551244)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 乳癌 / マイクロRNA / エストロゲンレセプター |
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| Research Abstract |
Expression profiles of microRNAs and mRNAs in estrogen receptor (ER)-positive breast cancer tissue were compared between ERhigh Ki67low tumors and ERlow Ki67high tumors by microRNA and mRNA microarrays. Unsupervised hierarchical clustering analyses revealed distinct expression patterns of miRNAs and mRNAs in these groups. We identified miR-1290 and its potential targets that might be associated with characteristics of ER-positive breast cancer.
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