2013 Fiscal Year Final Research Report
Basic study for personalized medicine of Graves' disease
| Project/Area Number |
23591909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Keywords | バセドウ病 / 個別化医療 / SNP |
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| Research Abstract |
We analyzed the gene of FMO3 in order to examine the possibility of the responsible gene of the agranulacytosis onset with Thiamazole(MMI) of the patients with Graves' disease. We analyzed the single nucleatide polymorphism(SNP) and all Exons of FMO3. The variations with four places of amino acid alterations were found. However, we are thought to be less likely to be associated with an onset-risk of agranulacytosis becasuse these variations are common in the general population.
It is extremely important to continue the search of the biomarker judging a side effect of MMI for the Graves' disease patients.
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