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2013 Fiscal Year Final Research Report

Analysis of cAMP/PKA signaling pathway in adenoma of primary hyperparathyroidism

Research Project

  • PDF
Project/Area Number 23591910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionFujita Health University

Principal Investigator

HIBI Ystsuka  藤田保健衛生大学, 医学部, 准教授 (10399024)

Co-Investigator(Kenkyū-buntansha) MIZUNO Yutaka  藤田保健衛生大学, 医学部, 講師 (90595977)
IMAI Tsuneo  名古屋大学, 医学部附属病院, 講師 (80252245)
KIKUMORI Toyone  名古屋大学, 医学部附属病院, 講師 (90402635)
IWASE Katsumi  藤田保健衛生大学, 医学部, 教授 (70148261)
Project Period (FY) 2011 – 2013
Keywords原発性副甲状腺機能亢進症 / PRKAR1α / PKA
Research Abstract

protein kinase A (PKA) regulatory subunit type 1a (R1a) is a major regulatory subunit that functions as an inhibitor of PKA kinase activity. Surgical specimens comprising 22 adenomas and 11 normal glands, obtained from 22 patients with primary hyperparathyroidism (PHPT), were analyzed. Western blot analysis revealed that 5 out oh 8 adenomas high expressed of R1a, compared with normal glands. PKA activity in adenoma was significantly less in normal glands. Immunohistochemical analysis further demonstrated high expression of R1a in 20 out of 22 adenomas. The study suggested that R1a expression could contribute to monoclonal proliferation of parathyroid cells by impairing the cAMP/PKA signaling pathway.

  • Research Products

    (10 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] 当施設のおける甲状腺全摘術での副甲状腺温存と術後の副甲状腺機能について2014

    • Author(s)
      日比八束
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 31巻 Pages: 14-18

  • [Journal Article] A MEN2A family with two asymptomatic carriers affected by unilateral renal agenesis2014

    • Author(s)
      Hibi Y, Ohye T, Ogawa K, Shimizu Y, Shibata M, Kagawa C, Mizuno Y, Kurahashi H, Iwase K.
    • Journal Title

      Endocr J.

      Volume: 61(1) Pages: 19-23

    • Peer Reviewed
  • [Journal Article] Unmasked renal impairment and prolonged hyperkalemia after unilateral adrenalectomy for primary aldosteronism coexisting with primary hyperparathyroidism : report of a case

    • Author(s)
      Hibi Y, Hayakawa N, Hasegawa M, Ogawa K, Shimizu Y, Shibata M, Kagawa C, Mizuno Y, Yuzawa Y, Itoh M, Iwase K.
    • Journal Title

      Surg Today

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Increased protein kinase A type Iαregulatory subunit expression in parathyroid gland adenomas of patients with primary

    • Author(s)
      Hibi Y, Kambe F, Imai T, Ogawa K, Shimizu Y, Shibata M, Kagawa C, Mizuno Y, Ito A, Iwase K.
    • Journal Title

      hyperparathyroidism

    • DOI

      10.1507/endocrj.EJ12-0267EndocrJ.2013;60(2):215-23

    • Peer Reviewed
  • [Presentation] KIDNEY FUNCTION OF PATIENTS WITH PRIMARY ALDOSTERONISM AFTER ADRENALECTOMY2014

    • Organizer
      14^<th> AAES CONGRESS
    • Place of Presentation
      Sri Lanka
    • Year and Date
      20140000
  • [Presentation] 甲状腺・内分泌外科の課題と展望当施設における原発性副甲状腺機能亢進症手術の検討2013

    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20130000
  • [Presentation] 当施設のおける甲状腺全摘術での副甲状腺温存と術後の副甲状腺機能について2013

    • Organizer
      第46回日本甲状腺外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20130000
  • [Presentation] 発性アルドステロン症に副甲状腺機能亢進症を合併した1例2013

    • Organizer
      第25回日本内分泌外科学会総会
    • Place of Presentation
      山形
    • Year and Date
      20130000
  • [Presentation] 副甲状腺機能亢進症における基礎・病理2012

    • Organizer
      第45回日本甲状腺外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20120000
  • [Presentation] TOTAL PARATHYROIDECTOMY WITH AUTOTRANSPLANTATION IN PATIENTS WITH ENDO-STAGE RENAL DISEASE IN TOTAL THYROIDECTOMY2012

    • Organizer
      13^<th> AAES CONGRESS
    • Place of Presentation
      Singapore
    • Year and Date
      20120000

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Published: 2015-07-16  

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