2013 Fiscal Year Final Research Report
The role of proton-sensing G-protein coupled receptors(GPCRs) in the regulation of inflammatory cytokine production during endoscopic surgery
| Project/Area Number |
23591916
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
MURATA Naoya 群馬県衛生環境研究所, 研究企画係, 研究員 (00533473)
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| Co-Investigator(Kenkyū-buntansha) |
OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
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| Project Period (FY) |
2011 – 2013
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| Keywords | プロトン感知性受容体 / OGR1受容体ファミリー / TDAG8 / 抗炎症性応答 |
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| Research Abstract |
The role of proton-sensing GPCRs in the regulation of lipopolysaccharide(LPS)-induced inflammatory cytokine production was investigated. In vivo injection of LPS into mice resulted in the remarkable accumulation of TNF-alpha. The LPS-induced action tends to be enhanced in the mice deficient in TDAG8 or GPR4; however, the effects of receptor deficiency were not significant. Extracellular acidification inhibited LPS-induced TNF-alpha protein and mRNA production in mouse peritoneal macrophages in vitro. Our results suggest that acidic pH inhibits inflammatory cytokine production at least partly through TDAG8/cAMP/PKA pathways in mouse macrophages.
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[Journal Article] Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model2013
Author(s)
Aoki H, Mogi C, Hisada T, Nakakura T, Kamide Y, Ichimonji I, Tomura H, Tobo M, Sato K, Tsurumaki H, Dobashi K, Mori T, Harada A, Yamada M, Mori M, Ishizuka T, and Okajima F.
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Journal Title
PLoS ONE
Volume: 8
Pages: e79985
DOI
Peer Reviewed
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[Journal Article] Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion2012
Author(s)
Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, and Okajima F.
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Journal Title
Endocrinology
Volume: 153
Pages: 4171-4180
DOI
Peer Reviewed
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[Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo2012
Author(s)
Komachi M, Sato K, Tobo M, Mogi C, Yamada T, Ohta H, Tomura H, Kimura T, Im DS, Yanagida K, Ishii S, Takeyoshi I, and Okajima F.
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Journal Title
Cancer Sci.
Volume: 103
Pages: 1099-1104
DOI
Peer Reviewed
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[Journal Article] Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells2011
Author(s)
Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, and Okajima F.
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Journal Title
Biochem Biophys Res Commun.
Volume: 413
Pages: 499-503
DOI
Peer Reviewed
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