2013 Fiscal Year Final Research Report
Fluorescence-guided detection and genetic analysis of circulating tumor cells
| Project/Area Number |
23591932
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Toshiyoshi 岡山大学, 大学院医歯薬学研究科, 教授 (00304303)
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| Co-Investigator(Renkei-kenkyūsha) |
TAZAWA Hiroshi 岡山大学, 病院, 助教 (90415513)
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| Research Collaborator |
SHIGEYASU Kunitoshi 岡山大学, 大学院医歯薬学研究科, 大学院生
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| Project Period (FY) |
2011 – 2013
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| Keywords | 末梢血循環腫瘍細胞 / アデノウイルス / 遺伝子解析 / 消化器癌 |
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| Research Abstract |
In addition to the conventional clinical information, molecular information obtained from cancer tissue is being used for proper selection of cancer therapy. The circulating tumor cells in the blood of cancer patients, if available, might be valuable source for such molecular information. We tried and succeeded to capture and analyze the rare tumor cells in the blood using a virus that can detect cancer cells with a fluorescent dye. This technology must be a novel molecular diagnostic method for cancer.
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Research Products
(10 results)
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[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases2013
Author(s)
Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
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Journal Title
Clinical Cancer Research
Volume: Vol. 19
Pages: 6495-6505
DOI
Peer Reviewed
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