2013 Fiscal Year Final Research Report
Gene expression analysis on chromosome 17q25.1 in esophageal squamous cell carcinoma
| Project/Area Number |
23591937
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Iwate Medical University (2012-2013)
Kyushu University (2011) |
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Principal Investigator |
IWAYA Takeshi 岩手医科大学, 医学部, 講師 (70405801)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Fumiaki (30332836)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食道癌 / 遺伝子発現 |
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| Research Abstract |
Tylosis is an autosomal dominant skin disorder that is associated with the early onset of esophageal squamous cell carcinoma (ESCC) in several families.The tylosis esophageal cancer (TOC) gene locus has been mapped to chromosome 17q25.1 using linkage analyses of pedigrees of such families. This region is also frequently lost in sporadic ESCC. Therefore, genes involved in the development of esophageal cancer may exist in the TOC region on 17q25.1. Among many genes in the region, significant downregulation of ST6GALNAC1 expression in esophageal cancer tissues was confirmed. Frequent mutation, loss of heterozygosity, and hypermethylation in ST6GALNAC1 gene were observed. Our results suggest that downregulation of ST6GALNAC1 via hypermethylation and LOH are associated with the development of ESCC.
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Author(s)
Takahashi Y, Sawada G, Kurashige J, Matsumura T, Uchi R, Ueo H, Ishibashi M, Takano Y, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Yamamoto H, Doki Y, Mori M, Mimori K.
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Volume: 29(3)
Pages: 946-50
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