2013 Fiscal Year Final Research Report
Development of a new fluorescence imaging system for peritoneal and lymph node metastasis of GI tract cancers
| Project/Area Number |
23591952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
ITO Yuichi 愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (80397463)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 蛍光イメージング / 腹腔鏡 / ICG近赤外蛍光 / 腹膜転移 / リンパ節転移 / 抗体プローブ |
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| Research Abstract |
Peritoneal and lymph node metastasis is the most frequent pattern of recurrence after curative surgery for gastric cancer. However, such a recurrence is difficult to detect by conventional CT and MRI at an early stage. In the present study, we first developed a new lymph node metastasis model using GFP-tagged tumor cells. Second, we developed a new laparoscopic fluorescence device for detecting metastasis using ICG-labeled antibody as a probe. Using these mouse metastasis model and imaging device, we successfully detected peritoneal metastasis and lymph node metastasis at an early stage with high sensitivity and specificity.
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[Journal Article] Induction of a pathological complete response by four courses of neoadjuvant chemotherapy for gastric cancer : early results of the randomized phase II COMPASS trial2014
Author(s)
Yoshikawa T, Tanabe K, Nishikawa K, Ito Y, Matsui T, Kimura Y, Hirabayashi N, Mikata S, Iwahashi M, Fukushima R, Takiguchi N, Miyashiro I, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J.
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Journal Title
Annals of Surgical Oncology
Volume: 21(1)巻
Pages: 213-9
DOI
Peer Reviewed
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[Journal Article] Accuracy of CT Staging of Locally Advanced Gastric Cancer after Neoadjuvant Chemotherapy : Cohort Evaluation within a Randomized Phase II Study2014
Author(s)
Yoshikawa T, Tanabe K, Nishikawa K, Ito Y, Matsui T, Kimura Y, Hasegawa S, Aoyama T, Hayashi T, Morita S, Miyashita Y, Tsuburaya A, Sakamoto J.
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Journal Title
Annals of Surgical Oncology
Volume: 21(3)巻
Pages: 385-9
DOI
Peer Reviewed
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