The combination therapy of the cancer-vaccine therapy and the preoperative chemoradiotherapy for rectal cancer (phase I trial)

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: TSURITA Giichiro 東京大学, 医科学研究所, 講師 (80345206)
• Co-Investigator(Kenkyū-buntansha): SHINOZAKI Masaru 東京大学, 医科学研究所, 准教授 (10312315) ; HATA Keisuke 東京大学, 医科学研究所, 助教 (60526755)
• Project Period (FY): 2011 – 2013
• Keywords: 直腸癌 / 術前放射線化学療法 / 癌ペプチド / 腫瘍特異的ワクチン療法 / 臨床試験 / 免疫療法

Research Abstract

This study was a phase I clinical trial of the therapy, combined preoperative chemoradiotherapy with tumor-specific vaccine therapy, for the cases with advanced rectal cancer. The purpose of this study was to examine the safety of this combination therapy. Unfortunately, this clinical trial, however the protocol of this clinical trial or the document of informed consent was prepared in the first year, was not able to be performed within research periods.
It was useful, however, in performing this clinical trial in future, to analyze the data of the advanced rectal cancer cases performed preoperative chemoradiotherapy, or to locate and educate not only medical doctors but also nurses, pharmacists, and medical technicians for this study.

Research Products

• [Journal Article] Impact of family history of gastric cancer on colorectal neoplasias in young Japanese (2013)
  • Author(s): Hata K, Shinozaki M, Toyoshima O, Toyoshima A, Matsumoto S, Saisho T, Tsurita G.
  • Journal Title: Colorectal Dis. Volume: 15(1) Pages: 42-6
  • Peer Reviewed
• [Journal Article] Case of secondary syphilis presenting with unusual complications : syphilitic proctitis, gastritis, and hepatitis (2011)
  • Author(s): Adachi E, Koibuchi T, Okame M, Sato H, Imai K, Shimizu S, Tsurita G, Oyaizu N, Iwamoto A, Fujii T.
  • Journal Title: J Clin Microbiol Volume: 49(12) Pages: 4394-6
  • Peer Reviewed
• [Journal Article] Is surveillance endoscopy necessary after colectomy in ulcerative colitis? (2011)
  • Author(s): Shuno Y, Hata K, Sunami E, Shinozaki M, Kawai K, Kojima T, Tsurita G, Hiyoshi M, Tsuno NH, Kitayama J, Nagawa H.
  • Journal Title: ISRN Gastroenterol
  • DOI: 10.5402/2011/509251
  • Peer Reviewed
• [Journal Article] 分子腫瘍マーカー‐治療経過と経過指標として (2011)
  • Author(s): 釣田義一郎,水野靖大,畑啓介,篠崎大,今井浩三
  • Journal Title: Current Therapy Volume: 29(12) Pages: 1104-8
• [Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer
  • Author(s): Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y.
  • Journal Title: PLoS One Volume: 9(1) Pages: 17(e85750)
  • DOI: 10.1371/.2014
  • Peer Reviewed
• [Presentation] 治癒切除不能大腸癌に対する積極的集学的治療の有効性についての検討 (2014)
  • Author(s): 釣田義一郎,谷澤健太郎,吉岡佑一郎,篠崎大
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03
• [Presentation] 標準治療が無効と判断された再発直腸癌に対してFOLFOX療法をやり直したところ長期生存が得られた1例 (2013)
  • Author(s): 釣田義一郎,畑啓介,谷澤健太郎,篠崎大
  • Organizer: 第68回日本消化器外科学会総会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-07-18
• [Presentation] The therapeutic strategy of the stage IV colorectal cancer (2012)
  • Author(s): Tsurita G, Shinozaki M, Hata K.
  • Organizer: XXV Biennial Congress of the International Society of University Colon & Rectal Surgeons
  • Place of Presentation: Bologna
  • Year and Date: 2012-06-06
• [Presentation] StageIV大腸癌の治療戦略 (2011)
  • Author(s): 釣田義一郎,篠崎大,水野靖大,畑啓介
  • Organizer: 第75回大腸癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-18