2013 Fiscal Year Final Research Report

New method for ulcerative colitis associated cancer

Research Project

Project/Area Number	23591960
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Mie University
Principal Investigator	ARAKI Toshimitsu 三重大学, 医学部附属病院, 講師 (70343217)
Co-Investigator(Kenkyū-buntansha)	KUSUNOKI Masato 三重大学, 大学院医学系研究科, 教授 (50192026) YOSHIYAMA Shigeyuki 三重大学, 医学部附属病院, 診療従事者 (60444436) OKITA Yoshiki 三重大学, 医学部, 助教 (20378342) MIKI Chikao 三重大学, 大学院医学系研究科, 客員教授 (50242962)
Project Period (FY)	2011 – 2013
Keywords	小腸大腸肛門外科学 / 潰瘍性大腸炎
Research Abstract	To clarify whether the expression of nitrative and oxidative DNA damage markers in the rectal mucosa of patients with ulcerative colitis (UC) could be used to predict UC-associated neoplasia. A total of 141 patients with UC who underwent a proctocolectomy were enrolled in this study. The expression of 8-nitroguanine (8-NG), 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), and inducible nitric oxide synthase (iNOS) in the rectal mucosa were evaluated using immunohistochemistry (IHC) and assessed relative to the pathogenesis of UC-associated neoplasia. The results suggest that evaluating the expression levels of 8-NG in the rectal mucosa may be a useful biomarker for detecting patients with UC-associated neoplasia.