2013 Fiscal Year Final Research Report
An establishment of new tumor dormancy therapy based on regulation of radical scavenger
| Project/Area Number |
23591967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITANO Seigou 大分大学, 法人本部, 学長 (90169871)
MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
NOGUCHI Takayuki 大分大学, 医学部, 病院長 (90156183)
ETOH Tsuyoshi 大分大学, 医学部, 講師 (00404369)
HIRATSUKA Takahiro 大分大学, 医学部, 医員 (20600886)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 小腸大腸肛門外科学 / 腫瘍学 |
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| Research Abstract |
We investigated whether new antioxidants, alfa-lipoic acid (ALA) delivertives and vitamin E delivertives elicits its antiproliferative effects in vivo and in vitro by inducing apoptosis, autophagy or cell cycle arrest, and we analyzed the expression of proteins related to these phenomena and their phosphorylation in HT-29 human colon cancer cells. These new antioxidants inhibited the proliferation of HT-29 cells through the mechanisms of G2/M cell cycle arrest and autophagy but not that of apoptosis. The newly synthesized ALA derivative may be expected to become a novel cancer therapeutic strategy through its induction of autophagy.
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Research Products
(10 results)
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[Journal Article] Antiproliferative effects of a newα-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro2012
Author(s)
Kono Y, Inomata M, Hagiwara S, Hiratsuka T, Suzuki K, Koga H, Shiraishi N, Noguchi T, Kitano S.
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Journal Title
Expert Opinion On Therapeutic Targets
Volume: 16
Pages: S103-109
DOI
Peer Reviewed
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