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2013 Fiscal Year Final Research Report

Functional analysis of CD133 in the maintenance of stemness mediated by ROS production in colon cancer cell.

Research Project

  • PDF
Project/Area Number 23591978
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionChiba Cancer Center (Research Institute)

Principal Investigator

SOUDA Hiroaki  千葉県がんセンター(研究所), 医療局・消化器外科, 研究員 (90261940)

Co-Investigator(Kenkyū-buntansha) SHIMOZATO Osamu  千葉県がんセンター(研究所), 発がん研究グループ, 上席研究員 (30344063)
Project Period (FY) 2011 – 2013
Keywords癌幹細胞 / CD133 / 活性酸素種
Research Abstract

As tyrosine residues of CD133 are phosphorylated in human colon cancer-derived cells, we sought for its functional significance in colon carcinogenesis. Consequently, we found that CD133 phosphorylation enhances xenograft tumor growth and sphere formation of colon cancer-derived cells. Additionally, we identified receptor-type protein tyrosine phosphatase  (PTPRK), a novel binding-partner of CD133, which dephosphorylates CD133 and thereby suppressing CD133-mediated oncogenic function. Indeed, lower PTPRK expression significantly correlated to the poor prognosis of colon cancer patients with higher expression of CD133. Thus, our present findings strongly suggest that inhibition of CD133 phosphorylation is a crucial issue for improving colon cancer treatment in future.

  • Research Products

    (4 results)

All 2014 2013 2011

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Receptor-type protein tyrosine phosphatasedirectly dephosphorylates CD133 and regulates downstream AKT activation2014

    • Author(s)
      Shimozato O, Souda H
    • Journal Title

      Oncogene

      Pages: 1-12

    • DOI

      10.1038/onc.2014.141

    • Peer Reviewed
  • [Journal Article] 同時多発遠隔転移のある大腸癌治療への取り組みと予後因子2013

    • Author(s)
      早田浩明(他9名)
    • Journal Title

      癌の臨床

      Volume: 59巻 Pages: 623-627

  • [Presentation] 膜結合型チロシン脱リン酸化酵素PTPRKによるチロシン脱リン酸化はがん幹細胞マーカーCD133の機能を負に制御する2013

    • Author(s)
      下里修、早田浩明(他4名)
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20131003-05
  • [Presentation] CD133 plays roles in keeping the undifferentiated status of human colon cancer cells via PI3K/AKT activation2011

    • Author(s)
      下里修(他5名)
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03

URL: 

Published: 2015-07-16  

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