2013 Fiscal Year Final Research Report
Identification of mechanism of hepatocarcinogenesis by analysi of microRNA
| Project/Area Number |
23591994
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
KUBO Shoji 大阪市立大学, 医学(系)研究科(研究院), 准教授 (80221224)
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| Co-Investigator(Kenkyū-buntansha) |
TAMORI Akihiro 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
MURAKAMI Yoshiki 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肝細胞癌 / がん遺伝子 / マイクロRNA / 生活習慣病 |
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| Research Abstract |
The mechanism of hepatocarcinogenesis was investigated using microRNA obtained from patients with hepatocellular carcinoma. The expression of 12 miRNA, especially miR-18b expression, varied significantly correlated to degree of histological differentiation. miR-18b can control the expression of trinucleotide repeat containing 6B as a target gene. Over-expression of miR-18b or down-regulation of TNCR6B accelerated cell proliferation and loss of cell adhesion ability. HCC patients with high miR-18b expression had a significantly shorter relapse-free period than those with low expression. miR-18b is a diagnostic and prognostic marker for HCC progression.
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