2013 Fiscal Year Final Research Report
Research of the impact of glucose dependent insurinotropic polypeptide on pancreatogenesis and on panreas cancer development
| Project/Area Number |
23592006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
KOIZUMI Masayuki 京都大学, 医学(系)研究科(研究院), その他 (90512351)
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| Co-Investigator(Kenkyū-buntansha) |
MASUI Toshihiko 京都大学, 医学研究科, 助教 (20452352)
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| Project Period (FY) |
2011 – 2013
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| Keywords | インクレチン / GIP / 膵癌 / 膵発生 |
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| Research Abstract |
There are several similarities between organogensis and carcinogenesis. In this study, we focused on one of the incretin family, GIP(glucose-dependent insulinotropic polypeptide) and analyzed the role of GIP on pancreatogenesis as well as on carcinogenesis of the panreas. Loss of GIP receptor in mouse embryo shows transition of the beta cell to the alpha cell in the developing pancreas, which implies GIP comittment on beta cell development. In the pancreatic cancer specimen, the expression of GIP receptor but not of GIP itself diminishes as the tumor develops from low grade PanIN to the authentic carcinoma. Moreover, the expression of GIP receptor concomitantly diminishes as the Pdx1 decreases in the pancreatic cancer. We previously reported Pdx1 tp be an unfavorable prognostic factor, and these results suggest that the GIP develops pancreatic cancer through Pdx1 during the initial stage of the pancreas carcrinogenesis.
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[Journal Article] Long-term survival after resection of pancreatic ductal adenocarcinoma with para-aortic lymph node metastasis : case report2013
Author(s)
Masui T, Kubota T, Aoki K, Nakanishi Y, Miyamoto T, Nagata J, Morino K, Fukugaki A, Takamura M, Sugimoto S, Onuma H, Tokuka A.
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Journal Title
World J Surg Oncol
Volume: 11(1)
Pages: 195
DOI
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[Journal Article] The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas2011
Author(s)
Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK.
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Journal Title
Diabetes
Volume: 60(2)
Pages: 548-54
DOI
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[Journal Article] A case of progressive digital ischemia after early withdrawal of gemcitabine and S-1 in a patient with systemic sclerosis2011
Author(s)
Zaima C, Kanai M, Ishikawa S, Kawaguchi Y, Masui T, Mori Y, Nishimura T, Matsumoto S, Yanagihara K, Chiba T, Mimori T.
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Journal Title
Jpn J Clin Oncol
Volume: 41(6)
Pages: 803-6
DOI
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[Journal Article] The distribution of atypical epithelium in main-duct type intraductal papillary mucinous neoplasms of the pancreas2011
Author(s)
Ito T, Doi R, Yoshizawa A, Sakikubo M, Nagai K, Kida A, Koizumi M, Masui T, Kawaguchi Y, Manabe T, Uemoto S.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 18(2)
Pages: 241-6
DOI
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[Journal Article] Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine2011
Author(s)
Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S.
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Journal Title
Nat Genet
Volume: 43(1)
Pages: 34-41
DOI
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[Journal Article] A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer2011
Author(s)
Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, Nishimura T, Mori Y, Masui T, Kawaguchi Y, Yanagihara K, Yazumi S, Chiba T, Guha S, Aggarwal BB.
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Journal Title
Cancer Chemother Pharmacol
Volume: 68(1)
Pages: 157-64
DOI
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