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2013 Fiscal Year Final Research Report

Identification of pancreatic stellate cell associated-microRNA that suppress tumor-stromal interaction and clarification of its mechanism.

Research Project

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Project/Area Number 23592012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

TOMINAGA Yohei  九州大学, 医学(系)研究科(研究院), 共同研究員 (90304823)

Co-Investigator(Kenkyū-buntansha) SATO Norihiro  産業医科大学, 医学(系)研究科(研究院), 助教 (20423527)
UEDA Jynji  九州大学, 大学病院, 助教 (90529801)
NABAE Toshinaga  九州大学, 医学研究院, 共同研究員 (10467889)
Co-Investigator(Renkei-kenkyūsha) MIZUMOTO Kazuhiro  九州大学, 大学病院, 准教授 (90253418)
Project Period (FY) 2011 – 2013
Keywords膵癌 / microRNA
Research Abstract

We analyzed microRNAs of pancreatic stellate cells(PSCs) derived from pancreatic cancer and normal pancreas. Microarray showed miR-31 and miR-34a increased in cancer associated PSCs and miR-21 decreased compared with normal PSCs. Next, we established highly metastatic pancreatic cancer cells to identify the miRs that associate with metastasis. In highly metastatic SUIT-2 cells(MSCs), microarray showed that miR-125b-5p, miR-4324 and miR-4706 increased and miR-16-5p, miR-21-5p, miR-192, miR-194 and miR-5100 decreased in MSCs compared with parent cells . In highly metastatic PANC-1 cells(MPCs), miR-1247-3p, miR-2964a-5p and miR-3135b increased and miR-377-5p, miR-4454 and miR-5100 decreased in MPCs compared with parent cells. We have identified several miRNAs from pancreatic stellate cell, highly metastatic pancreatic cancer cells and IPMN that has possibility of becoming markers for prognostic value of pancreatic cancer.

  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (4 results) Presentation (4 results)

  • [Journal Article] Elevated Expression Level of MicroRNA-196a Is Predictive of Intestinal-Type Intraductal Papillary Mucinous Neoplasm of the Pancreas2013

    • Author(s)
      Aso T, Ohtsuka T, Tamura K, Ideno N, Kono H, Nagayoshi Y, Ohuchida K, Ueda J, Takahata S, Shindo K, Aishima S, Oda Y, Mizumoto K, Tanaka M.
    • Journal Title

      Pancreas

      Volume: 43(3) Pages: 361-366

  • [Journal Article] Migratory activity of CD105+ pancreatic cancer cells is strongly enhanced by pancreatic stellate cells2013

    • Author(s)
      Kenji Fujiwara, Kenoki Ohuchida, Takao Ohtsuka, Kazuhiro Mizumoto, Koji Shindo, Naoki Ikenaga, Lin Cui, Shunichi Takahata, Shinichi Aishima, and Masao Tanak
    • Journal Title

      Pancreas

      Volume: 42(8) Pages: 1283-90

  • [Journal Article] MAL2 expression predicts distant metastasis and short survival in pancreatic cancer2013

    • Author(s)
      Daiki Eguchi, Kenoki Ohuchida, Shingo Kozono, Naoki Ikenaga, Koji Shindo, Lin Cui, Kenji Fujiwara, Shin Akagawa, Takao Ohtsuka, Shunichi Takahata, Shoji Tokunaga, Kazuhiro Mizumoto, Masao Tanaka
    • Journal Title

      Surgery

      Volume: 154(3) Pages: 573-82

  • [Journal Article] CD271 subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells

    • Author(s)
      Fujiwara K, Ohuchida K, Mizumoto K, Shindo K, Eguchi D, Kozono S, Ikenaga N, Ohtsuka T, Takahata S, Aishima S, Tanaka M.
    • Journal Title

      PLoS One

      Volume: 7(12) Pages: e52682

  • [Presentation] 腸型膵管内乳頭粘液性腫瘍(IPMN)におけるmicroRNA-196aの高発現2013

    • Author(s)
      安蘇鉄平
    • Organizer
      第113回日本外科学会定期学術集会
    • Year and Date
      20130000
  • [Presentation] 膵癌におけるCD271陽性膵星細胞の意義2012

    • Author(s)
      藤原謙次
    • Organizer
      第112回日本外科学会定期学術集会
    • Year and Date
      20120000
  • [Presentation] CD10陽性膵星細胞は膵癌の進展を促進する2011

    • Author(s)
      池永直樹
    • Organizer
      第111回日本外科学会定期学術集会
    • Year and Date
      20110000
  • [Presentation] 膵癌における膵星細胞およびその癌間質相互作用を標的とした新しい膵癌治療の可能性2011

    • Author(s)
      小薗真吾
    • Organizer
      第22回日本消化器癌発生学会総会
    • Year and Date
      20110000

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Published: 2015-07-16  

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