2013 Fiscal Year Final Research Report
The prevention of perioperative mortal arrhythmia : the effect of Granulocyte-Colony Stimulating Factor Administration
| Project/Area Number |
23592025
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 心臓大血管外科学 / 致死性不整脈 / 顆粒球コローニー刺激因子 / 集中治療学 |
|---|
| Research Abstract |
The antiarrhythmic effect of Granulocyte colony-stimulating factor (G-CSF) on hypertrophic cardiomyopathy (HCM) has not been clarified. Salt-sensitive rats were maintained on a high-salt diet as HCM models (n=17) and a low-salt as normal heart models (NH; n=5). After the treatments with 50microg/kg (i.p.) of G-CSF (9 HCMs and 2 NHs) and vehicle (8 HCMs and 3 NHs), rapid ventricular pacing was performed to evaluate the vulnerability to VT. The G-CSF reduced inducibility of VT as compared to vehicle in HCM (1 of 9 vs. 5 of 8, p=0.03). In addition, VT was not inducible in NH treated with G-CSF, although it was inducible in 1 of 3 NHs treated with vehicle. The G-CSF increased the phosphorylated Connexin-43 level as compared to vehicle in both HCM (1.4-fold vs. 1.2-fold, p<0.01) and NH (1.4-fold vs. 1-fold, p=0.04). The G-CSF is proposed as an antiarrhythmic agent in patients with HCM, because it reduces the vulnerability to VT by up-regulating the phosphorylated Connexin-43.
|
-
-
-
[Journal Article] Significant reversal of cardiac upregulated endothelin-1 system in a rat model of sepsis by landiolol hydrochloride2014
Author(s)
Yoshimoto Seki, Subrina Jesmin, Nobutake Shimojo, Majedul Islam, Arifur Rahman, Tanzila Khatun, Hidekazu Sakuramoto, Masami Oki, Aiko Sonobe, Junko Kamiyama, Keiichi Hagiya, Satoru Kawano, Taro Mizutani
-
Journal Title
Life Sci.
Volume: S0024-3205(14)
Pages: 00405-6
Peer Reviewed
-
[Journal Article] Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model2014
Author(s)
Masami Oki, Subrina Jesmin, Majedul Islam, Chinba N Mowa, Tanzila Khatun, Nobutake Shimojo, Hideaki Sakuramoto, Junko Kamiyama, Satoru Kawano, Takashi Miyauchi, Taro Mizutani
-
Journal Title
Life Sci.
Volume: S0024-3205(14)
Pages: 00238-0
Peer Reviewed
-
[Journal Article] Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice2013
Author(s)
Kazuko Tajiri, Nobutake Shimojo, satoshi Sakai, Tomoko Machino-Ohtsuka, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Yoshiko Tsujimura, Taizo Kimura, Akira Sato, Yasuhiro Yasutomi, Kazutaka Aonuma
-
Journal Title
Cardiovasc Drugs Ther
Volume: 27(5)
Pages: 413-24
DOI
Peer Reviewed
-
[Presentation] Effects of landiolol hydrochloride, an ultra-short-actingβ-blocker, on cardiac endothelin system in a rat model of endotoxemia : a possible relevance with cardiac functional compensatory events at the early phase of sepsis2013
Author(s)
Yoshimoto Seki, Nobutake Shimojo, Jesmin Subrina, Majedul Islam, Tanzila Khatun, Hideaki Sakuramoto, Junko Kamiyama, Keiichi Hagiya, Satoru Kawano, Taro Mizutani
Organizer
International Conference on Endothelin
Place of Presentation
Tokyo, Japan
Year and Date
2013-09-11
-
-
-
-
-
