2013 Fiscal Year Final Research Report
Treatment for severe heart failure using human plancenta derived mesenchymal cells and differentiation inducing molecule to myocardiocytes
| Project/Area Number |
23592047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIDA Naoko 慶應義塾大学, 医学部, 特任助教 (70360112)
KIMURA Takehiro 慶應義塾大学, 医学部, 特任助教 (20449002)
MIYOSHI Shunichiro 慶應義塾大学, 医学部, 講師(非常勤) (10296577)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 幹細胞 / 間葉系 / 細胞移植 / 低侵襲 / 内視鏡 / 心不全 |
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| Research Abstract |
1)Establishment of cell implantation technique using pericardial endoscopy
In beagle dogs, pericardial endoscope was placed in pericardial space using Seldinger technique and the view in the pericardial space was afforded. Specialized technique to work in the small pericardial space, optimized devise, and tools for cell transplant to the epicardium were developed. Human plancenta derived mesenchymal cells were successfully implanted to the left ventricle of beagle dogs. Pacing wire implantation under pericardial endoscopic view was also performed.
To find factors to enhance differentiation to the cardiomyocyte from mesenchymal cells, several candidate molecules were verified.
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Research Products
(26 results)
