2013 Fiscal Year Final Research Report
The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung
| Project/Area Number |
23592066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TSUCHIYA Tomoshi 長崎大学, 医歯(薬)学総合研究科, 講師 (30437884)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYASU Takeshi 長崎大学, 大学院医歯薬学総合研究科, 教授 (80284686)
SHIMOKAWA Isao 長崎大学, 大学院医歯薬学総合研究科, 教授 (70187475)
YAMASAKI Naoya 長崎大学, 大学院医歯薬学総合研究科, 講師 (70404217)
AKITA Sadanori 長崎大学, 大学病院, 講師 (90315250)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGAMI Yoshikazu 東京理科大学, 薬学部, 教授 (90253640)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 虚血再灌流障害 / 肺移植 / 脂肪幹細胞 / PARP inhibitor |
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| Research Abstract |
In the starting up study, we established rat ischemia-reperfusion model using hilar clumping. Using the model, we could show that PARP-1 inhibitor prevent the tissue injury. The study was accepted in the journal of Transplantation. In the study of adipose tissue derived stromal cells, we established rat lung transplantation model and used the cells to prevent tissue rejection. Interestingly, adipose tissue derived stromal cells enhanced the effects of immunosuppressant.
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