2013 Fiscal Year Final Research Report

The new approach method for the vascularization mechanism elucidation of the non-small-cell lung cancer and the clinical application

Research Project

Project/Area Number	23592069
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	Kumamoto University
Principal Investigator	SUZUKI Makoto 熊本大学, 大学院生命科学研究部, 教授 (80312940)
Co-Investigator(Kenkyū-buntansha)	IKEDA Koei 熊本大学, 医学部附属病院, 助教 (20448525)
Project Period (FY)	2011 – 2013
Keywords	非小細胞肺癌 / 血管新生 / SLIT2
Research Abstract	We examined a role of five genes ( LINE-1, SLIT2, MAL, IGFBP7, IRF8 ) including the gene which relates to angigogenesis, in terms of the carcinogenesis and invasion of non-small cell lung cancer (NSCLC). As a result, in NSCLC, LINE-1 was hypomethylated and expressions of other SLIT2, MAL, IGFBP7, and IRF8 were lowered by hypermethylation of their genes. Because the changes were tumor-specific when compared with non-malignant lung tissues, further study will clarify the mechanism of carcinogenesis of NSCLC and will contribute to the new treatment of NSCLC.