2013 Fiscal Year Final Research Report

Construction of an artificial trachea using newly developed tissue engineering technique

Research Project

Project/Area Number	23592071
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	Nara Medical University
Principal Investigator	NAITO HIROSHI 奈良県立医科大学, 医学部, 研究員 (00316069)
Project Period (FY)	2011 – 2013
Keywords	再生医療 / 組織工学 / 人工気管 / 骨芽細胞 / 間葉系幹細胞
Research Abstract	We constructed an artificial trachea, which made from soft tube-shaped tissue and hard ring-shaped tissue, which had similar structure with native trachea. Tube-shaped tissue was constructed from fibroblasts and ring-shaped tissue was constructed from mesenchymal stem cells. Mesenchymal stem cells were induced differentiation into osteoblasts during ring-shaped tissue construction, and this differentiation increased mechanical strength of the tissue. This artificial trachea was transplanted into rat trachea and which showed the potential for usage.