Development of diagnostic imaging for detection of epileptogenic foci

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592089
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: KATO Hiroki 大阪大学, 医学(系)研究科(研究院), 助教 (20448054)
• Co-Investigator(Kenkyū-buntansha): HATAZAWA Jun 大阪大学, 大学院医学系研究科, 教授 (70198745)
• Project Period (FY): 2011 – 2013
• Keywords: 脳・神経 / 分子イメージング / PET / SPECT / てんかん / 脳血管障害

Research Abstract

Detection of epileptogenic foci in intractable epilepsy is most important for planning of operative therapy. Development of low-invasive and accurate method for diagnostic imaging is expected. We suggested, based on a previous pilot study conducted in a small number of patients, that MRI-based partial volume effect correction (PVC) in I-123 iomazenil brain SPECT improves the detectability of cortical epileptogenic foci. In the present study, the effectiveness of MRI-based PVC in I-123 iomazenil brain SPECT in improving the detection of cortical epileptogenic foci was established by the investigation conducted on a relatively large sample size. In addition, we established experimental environment to develop PET and/or MRI imaging methods for small animal models of cerebrovascular disease or epilepsy. We made chronic cerebral hypoperfusion model rats, and evaluated their cerebral blood flow, cerebral oxygen metabolism, and brain inflammation by using these imaging modalities.

Research Products

• [Journal Article] 脳機能と核医学イメージング (2013)
  • Author(s): 加藤弘樹,畑澤順
  • Journal Title: PETジャーナル Volume: 21 Pages: 39-40
• [Journal Article] CBF measurement using an integrated SPECT/CT system : validation of three-dimensional ordered-subset expectation maximization and CT-based attenuation correction by comparing with O-15 water PET (2013)
  • Author(s): Shimosegawa, E. Fujino, K. Kato, H. Hatazawa, J
  • Journal Title: Ann Nucl Med Pages: 27
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of cerebral blood flow and oxygen metabolism in normal anesthetized rats: 15O-labeled gas inhalation PET with MRI Fusion (2013)
  • Author(s): Watabe, T. Shimosegawa, E. Watabe, H. Kanai, Y. Hanaoka, K. Ueguchi, T. Isohashi, K. Kato, H. Tatsumi, M. Hatazawa, J.
  • Journal Title: J Nucl Med Volume: 54 Pages: 283-290
  • Peer Reviewed
• [Journal Article] Distribution of cortical benzodiazepine receptor binding in right-handed healthy humans : A voxel-based statistical analysis of iodine 123 iomazenil spect with partial volume correction (2012)
  • Author(s): Kato H, Shimosegawa E, Isohashi K, Kimura N, Kazui H, Hatazawa J
  • Journal Title: AJNR Am J Neuroradiol Volume: 33 Pages: 1458-1463
  • Peer Reviewed
• [Journal Article] Mr imaging-based correction for partial volume effect improves detectability of intractable epileptogenic foci on iodine 123 iomazenil brain spect images : An extended study with a larger sample size (2012)
  • Author(s): Kato H, Matsuda K, Baba K, Shimosegawa E, Isohashi K, Imaizumi M, Hatazawa J
  • Journal Title: AJNR Am J Neuroradiol Volume: 33 Pages: 2088-2094
  • Peer Reviewed
• [Journal Article] 核医学画像診断成人病と生活習慣病
  • Author(s): 加藤弘樹
  • Journal Title: 若年性脳血管障害 Volume: 42 Pages: 1439-1445
• [Presentation] SPECT/CT導入による脳血流SPECTの血流低下検出能への影響 (2014)
  • Author(s): 加藤弘樹、礒橋佳也子、石橋愛、渡部直史、金井泰和、下瀬川恵久、畑澤順
  • Organizer: 第43回日本神経放射線学会
  • Year and Date: 20140321-23
• [Presentation] 虚血性脳血管障害の核医学診断 (2014)
  • Author(s): 加藤弘樹
  • Organizer: 第39回脳卒中学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20140313-15
• [Presentation] 形態画像を用いた核医学画像解析脳:MRを用いた部分容積効果補正 (2013)
  • Author(s): 加藤弘樹
  • Organizer: 第53回日本核医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20131108-10
• [Presentation] 11C-acetate PETによる多発性硬化症における活性化アストロサイトのin vivo評価 (2013)
  • Author(s): 加藤弘樹
  • Organizer: 第25回日本脳循環代謝学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20131101-02
• [Presentation] Difference in detectability of brain SPECT count reduction by voxel-based statistical analysis depending on attenuation correction methods (2013)
  • Author(s): Kato H, Ishibashi M, Isohashi K, Tatsumi M, Shimosegawa E, Naka S, Kanai Y, Watabe H, Hatazawa J
  • Organizer: SNMMI 2013 Annual Meeting
  • Place of Presentation: Vancouver, BC, Canada
  • Year and Date: 20130608-12
• [Presentation] 統計画像解析による脳SPECTの集積低下検出感度に関する吸収補正法の影響について (2012)
  • Author(s): 加藤弘樹
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 20121011-13
• [Presentation] Difference in voxel count variations in brain SPECT normal database depending on attenuation correction methods (2012)
  • Author(s): Kato H
  • Organizer: SNM 2012 Annual Meeting
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 20120609-13
• [Presentation] Shimosegawa E,Imaizumi M. Hatazawa J.Lateral asymmetry of benzodiazepine receptor binding in right-handed healthy human cortices : Partial volume correction for voxel based statistical analysis of I-123 iomazenil SPECT (2012)
  • Author(s): Kato H
  • Organizer: SNM 2011 Annual Meeting
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 20120604-08