2013 Fiscal Year Final Research Report
Study of cancer microenvironment in brain metastasis using circulating tumor cells
| Project/Area Number |
23592133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
TANAKA Kunihiko 長崎大学, 医歯(薬)学総合研究科, 准教授 (80380955)
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| Co-Investigator(Renkei-kenkyūsha) |
TOYODA Keisuke 長崎大学, 大学病院, 医員 (40597366)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳転移 / 血中循環がん細胞 / がん微小環境 |
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| Research Abstract |
The direct cause of death of cancer, which is the leading cause of death in Japanese, is metastasis. Above all, brain metastasis is developed by cancer cells' intravasating,extravasating, and proloferating in the brain. The purpose of our project was to investigate how the circulating tumor cells get into the brain, adapt to the microenvironment, and proliferate in the brain. We established highly-brain metastatic cancer cells which were expressing green fluorescent protein and succeeded in developing new system in which the brain microenvironment was reconstructed in vitro. Using the system, we clarified that different types of cancer cells showed the different ways of proliferating in the brain.
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