2013 Fiscal Year Final Research Report
Simultaneous gradual lengthening of proximal and distal nerve stumps for repair of chronic peripheral nerve defect.
| Project/Area Number |
23592155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OCHIAI Naoyuki 筑波大学, その他部局等, 名誉教授 (30134563)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIURA Yasumasa 筑波大学, 医学医療系, 教授 (80208131)
HARA Yuki 筑波大学, 医学医療系, 講師 (30431688)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医学 / 神経科学 / 末梢神経伸長 / 神経欠損治療 |
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| Research Abstract |
We investigated nerve regeneration of rat sciatic nerves after chronic injury of 15 mm-defect by the gradual lengthening of proximal and distal nerve stumps. In the lengthened proximal stump, Schwann cells and axons existed along the whole nerve stump. In the lengthened distal stump, Schwann cells exist along the overall length. The whole nerve trunk was lengthened.
The nerve regeneration was comparable with the delayed end-to-end suture without nerve defect. We showed the feasibility of direct gradual lengthening of proximal and distal nerve stumps for the treatment of chronic segmental nerve defect.
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