2013 Fiscal Year Final Research Report
Developement of a caffeine-assisted chemotherapy against bone tumors using a novel DDS by Span80 vesicles
| Project/Area Number |
23592191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Ehime University |
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Principal Investigator |
KIDANI Teruki 愛媛大学, 医学部附属病院, 講師 (60380234)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZAKI Tatsuhiko 岐阜大学, 医学部付属病院, 准教授 (80239384)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 骨・軟部腫瘍学 / カフェイン / 骨肉腫 / DDS / 化学療法モデル / Span80ベシクル |
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| Research Abstract |
In order to develop a novel therapeutic model by a novel tumor-specific drug delivery system (DDS), we tried a novel DDS by span80 nano-vesicles containing anti-tumor agent in vitro and in vivo with osteosarcoma bearing mouse model. As a result, we established a novel therapeutic model using caffeine and ifosfamide containing Span80 vesicles which manifested prominent efficiency and almost no adverse effect.
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