2013 Fiscal Year Final Research Report
Development of an oncolytic virus targeting sarcoma as a biological agent
| Project/Area Number |
23592203
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
|---|
Principal Investigator |
YAMAMURA Hisako 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 研究員 (50342994)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Katsuhito 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 研究員 (40211338)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 腫瘍溶解性ウイルス / カルポニン / 肉腫 / 中皮腫 |
|---|
| Research Abstract |
d12.CALPfdeltaRR and d12.ODDdeltaRR were purified using a Vero designer cells which were carried out biological safety evaluation. Those two oncolytic HSV-1 viruses were tested their anti-tumor activity using malignant fibrous histiocytoma (MFH) which can be maintained in immuno-competent Fisher rats.
We established 3D-spheroids cultures of human primary sarcoma cells, analysed RNA expression and tested their sensitivity to anti-tumor drugs.
|
