2013 Fiscal Year Final Research Report
A study on the treatment of post anesthesia and surgical sleep disturbance
| Project/Area Number |
23592242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
KUSHIKATA Tetsuya 弘前大学, 医学(系)研究科(研究院), 准教授 (80250603)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Kazuyoshi 弘前大学, 医学研究科, 教授 (20238413)
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| Co-Investigator(Renkei-kenkyūsha) |
HITOSHI Yoshida 弘前大学, 医学研究科, 講師 (00374843)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 麻酔 / 睡眠障害 |
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| Research Abstract |
Sleep disturbance after anesthesia and surgery could affect post-operative prognosis. It may cause ischemic heart disease or cerebral hemorrhage; thus to treat the sleep disturbance is one of notable issue in current anesthetic practice. We examined whether several anesthetics affect on sleep-wakefulness related neuropeptide using rat. These include neuropeptide S (NPS) and orexin (OX) that are well-documented endogenous sleep-wakefulness related neuropeptide. Ketamine and propofol, which are widely used in clinical practice, modified content of them in the rat brain. NPS decreased anesthesia time by both anesthetics. In addition, a NPS receptor enhanced physiological sleep in rats. These results indicated that anesthetics affected the sleep-wakefulness related neuropeptide and the peptides modified anesthetic status. We propose, with these results, that to control endogenous sleep-wakefulness related neuropeptide could provide some solution how to treat the sleep disturbance.
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