2013 Fiscal Year Final Research Report
Intracellular signaling of proliferation and differentiation in vascular smooth muscle cells
| Project/Area Number |
23592247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANABE Kumiko 岐阜大学, 医学部附属病院, 講師 (30402209)
IIDA Hiroki 岐阜大学, 医学部附属病院, 教授 (30159561)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血管平滑筋細胞 / 動脈硬化 / 創傷治癒 / 静脈麻酔薬 / 細胞内情報伝達 |
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| Research Abstract |
Intravenous anesthetics are used during the perioperative and/or postoperative period in critically ill patients. Intravenous anesthetics are firmly established to have direct effects on vascular smooth muscle cells. In the present study, we investigated the effects of intravenous anesthetics on PDGF-BB-induced VSMC migration and the mechanism. Our results strongly suggest that propofol or midazolam inhibits VSMC migration by PDGF-BB via suppression of p38 MAPK activation. Propofol or midazolam may affect VSMC function in critically ill patients.
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