2013 Fiscal Year Final Research Report
Intracellular signaling of neuroprotection by general anesthetics
| Project/Area Number |
23592248
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
TANABE Kumiko 岐阜大学, 医学部附属病院, 講師 (30402209)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOZAWA Osamu 岐阜大学, 医学系研究科, 教授 (90225417)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 全身麻酔薬 / 中枢神経保護 / サイトカイン / アストロサイト |
|---|
| Research Abstract |
General anesthetics are reportedly to have neuroprotective effects. However, the detailed intracellular mechanisms have not been fully clarified. We investigated effects of intravenous anesthetics on neurotrophic factor or cytokine release from rat glioma cell line, C6 cells. In conclusion, midazolam or dexmedetomidine suppressed IL-1beta-induced IL-6 release. Midazolam inhibited IL-1beta-induced IL-6 via suppression of STAT3 phosphorylation in C6 glioma cells. However, exact mechanism of dexmedetomidine in IL-1beta-induced IL-6 release was not elucidated.
|
