2013 Fiscal Year Final Research Report
The study on functions of opioid receptors expressed in T lymphocytes
| Project/Area Number |
23592252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto University |
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Principal Investigator |
SHODA Takehiro 京都大学, 医学(系)研究科(研究院), 助教 (60335263)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMURA Tomio 滋賀医科大学, 医学部, 教授 (70152337)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 麻薬 / モルヒネ / Tリンパ球 |
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| Research Abstract |
Narcotics have been reported to develop immunosuppression as one of their side effects, the mechanism of which might be involved in opioid receptors expressed on immune cells, such as T lymphocytes.
We have cloned before, from human T cell cDNA library, the cDNA encoding a splice variant of kappa opioid receptor, truncated at its amino terminus (termed as KOR4). The stable transformants of HEK293 cells heterologously transfected with KOR4 cDNA are now being constructed and characterization of KOR4 will be investigated. Moreover, we have demonstrated that, in human T lymphocytes and Jurkat cells, signaling pathways by T cell receptor stimulation would be alterd by morphine pretreatment. These results suggest that narcotics could change T cell functions and modulate immune systems.
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