2013 Fiscal Year Final Research Report
Neuroprotective effect of fructose water-soluble alpha-lipoic acid: a 31P-NMR study
| Project/Area Number |
23592259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOKUMARU Osamu 大分大学, 医学部, 准教授 (40360151)
YOKOI Isao 大分大学, 医学部, 教授 (80150366)
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| Project Period (FY) |
2011 – 2013
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| Keywords | αリポ酸 / 脳保護 / フリーラジカル / 虚血再灌流負荷 / 核磁気共鳴法 / 電子スピン共鳴法 / ラジカルスカベンジャー / 高エネルギーリン酸 |
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| Research Abstract |
Despite its strong antioxidative and anti-inflammatory activity, application of alpha-lipoic acid has been limited due to its water-insolubility. The neuroprotective effect of a newly-developed water-soluble derivative of alpha-lipoic acid was studied using 31P-nuclear magnetic resonance spectroscopy. The recovery of high-energy phosphates, ATP and phosphocreatine (energetic buffer of ATP in living cells), was significantly higher when brain slices were superfused with water-soluble alpha-lipoic acid. The electron spin resonance spectroscopy indicated a wide range of free radical scavenging activity of the water-soluble alpha-lipoic acid.
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