2013 Fiscal Year Final Research Report
Effects of inhalation and intravenous anesthetic drugs for Ca2+ uptake capacity and respiratory function in mitochondria of the platelets.
| Project/Area Number |
23592267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWASE Naoto 長崎大学, 大学院医歯(薬)学総合研究 科, 教授 (40408141)
ANDO Chihiro 東京医科大学, 医学部, 助教 (50420980)
TOMINO Mikiko 東京医科大学, 医学部, 助教 (30459523)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHINO Hiroyuki 東京医科大学, 医学部, 主任教授 (60266476)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ミトコンドリア / 麻酔薬 |
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| Research Abstract |
In freshly isolated and permeabilized human platelets the commonly used anesthetic agents sevoflurane and propofol stimulate certain aspects of mitochondrial res- piratory capacity at clinically relevant concentrations. At higher concentrations, these agents displayed a dose- dependent inhibition of complex I and II-supported res- piration. The increased respiratory capacity induced by sevoflurane and propofol might be beneficial and the inhibition of respiration could be relevant to situa- tions of prolonged or excessive exposure, especially in situations of tissue accumulation of these anesthetic agents.
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Research Products
(1 results)
