2013 Fiscal Year Final Research Report
Association of epigenetic modulation in the TACR1 gene with opioid-induced nausea and vomiting
| Project/Area Number |
23592301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAKAGE Michiaki 札幌医科大学, 医学部, 教授 (70285005)
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| Research Collaborator |
HAYASE Tomo 札幌医科大学, 医学部, 助教 (20579007)
TACHIBANA Shun-suke 札幌医科大学, 医学部, 大学院生
NAWA Yuko 札幌医科大学, 医学部, 助教 (90586794)
MORIYA Hiroyuki 北海道薬科大学, 薬学部, 助教 (00337049)
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| Project Period (FY) |
2011 – 2013
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| Keywords | エピジェネティクス / 悪心嘔吐 / 遺伝子 / 麻酔 |
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| Research Abstract |
We hypothesized that regulation of the TACR1 gene is involved in the individual differences in severity of postoperative nausea and vomiting (PONV). We examined CpG methylation of the promoter region of the TACR1 gene, which modulates NK1 receptor expression in both human blood and mouse the brain. The results of the current study showed that the level of methylation was inversely correlated with the intensity of PONV. This new finding may contribute to preoperative prediction of the severity of PONV in surgical patients.
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