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2013 Fiscal Year Final Research Report

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Research Project

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Project/Area Number 23592329
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

OZONO Seiichiro  浜松医科大学, 医学部, 教授 (00183228)

Co-Investigator(Kenkyū-buntansha) TAKAYAMA Tatsuya  自治医科大学, 医学部, 准教授 (90324350)
TAKAOKA Naohisa  浜松医科大学, 医学部, 特任研究員 (30467229)
SUGIYAMA Takayuki  浜松医科大学, 医学部, 助教 (70444346)
Project Period (FY) 2011 – 2013
Keywords腫瘍学
Research Abstract

We are searching a marker gene of kidney cancer and we pay attention to brain type fatty acid-binding protein (FABP7) as the candidate and push forward a study. We performed analysis about the influence of long chain unsaturated fatty acid on a kidney cancer thence. High concentration of long chain unsaturated fatty acid tends to suppress cell proliferation of kidney cancer cell strains, and these inhibitions tend to occur at low concentration with the omega-3 fatty acid than the omega-6 fatty acid. In addition, inhibition of cell proliferation with the DHA occurred with low concentration when cells expressed FABP7 gene. It would expect that expression of FABP7 gene would restrain cell proliferation of a kidney cancer at the condition adding the DHA.

  • Research Products

    (21 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (10 results) Book (3 results)

  • [Journal Article] Impact of Gender in Renal Cell Carcinoma : The Relationship of FABP7 and BRN2 Expression with Overall Survival2014

    • Author(s)
      Tan C, Takayama T, Takaoka N, Fujita H, Miyazaki M, Sugiyama T, Ozono S
    • Journal Title

      Clin Med Insights Oncol

      Volume: 8 Pages: 7-21

    • DOI

      10.4137/CMO.S13684

    • Peer Reviewed
  • [Journal Article] 腹腔鏡下根治的腎摘除術を施行したpT1N0M0腎癌の長期成績2013

    • Author(s)
      高山達也,甲斐文丈,杉山貴之,永田仁夫,鶴信雄,古瀬洋,伊原博行,栗田豊,麦谷荘一,牛山知己,鈴木和雄,大園誠一郎
    • Journal Title

      Jpn J Endourol

      Volume: 26 Pages: 83-86

    • DOI

      10.11302/jsejje.26.83

    • Peer Reviewed
  • [Journal Article] Current Organ Topics:Genitourinary Tumor泌尿器系腫瘍I2013

    • Author(s)
      大園誠一郞
    • Journal Title

      パラダイムシフトした腎癌薬物療法、癌と化学療法

      Volume: 40 Pages: 36-40

  • [Journal Article] T1a腎癌における再発危険因子2012

    • Author(s)
      高山達也,杉山貴之,甲斐文丈,麦谷荘一,大園誠一郎
    • Journal Title

      腎癌研究会会報

      Volume: 42 Pages: 106

  • [Journal Article] Characteristics of aggressive variants in T1a renal cell carcinoma2011

    • Author(s)
      Takayama T, Sugiyama T, Kai F, Suzuki T, Nagata M, Imanishi T, Mizuno T, Sato S, Furuse H, Mugiya S, Ozono S
    • Journal Title

      J Cancer Res Clin Oncol

      Volume: 137 Pages: 9-1653

    • DOI

      10.1007/s00432-011-1040-y

  • [Journal Article] Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines2011

    • Author(s)
      Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S
    • Journal Title

      BMC Mol Biol1

      Volume: 2 Pages: 31

    • DOI

      10.1186/1471-2199-12-31

    • Peer Reviewed
  • [Journal Article] Combined immunotherapy with low-dose IL-2 plus IFN-alpha for metastatic renal cell carcinoma : survival benefit for selected patients with lung metastasis and serum sodium level2011

    • Author(s)
      Akaza H, Tsukamoto T, Fujioka T, Tomita Y, Kitamura T, Ozono S, Miki T, Naito S, Zembutsu H, Nakamura Y
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Pages: 1023-1030

    • DOI

      10.1093/jjco/hyr067

    • Peer Reviewed
  • [Journal Article] Should ipsilateral solitary adrenal involvement in renal cell carcinoma be staged as M1?2011

    • Author(s)
      Takayama T, Sugiyama T, Kai F, Ito T, Furuse H, Mugiya S, Ozono S
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41 Pages: 6-792

    • DOI

      10.1093/jjco/hyr031

    • Peer Reviewed
  • [Presentation] 腎癌細胞株での脳型脂肪酸タンパク質FABP7の機能解析

    • Author(s)
      高岡直央、宮崎美紀、藤田博美、古瀬洋、杉山貴之、大園誠一郎
    • Organizer
      第23回泌尿器科分子・細胞研究会
  • [Presentation] 脂肪酸結合蛋白質7による腎癌細胞株の細胞増殖の抑制

    • Author(s)
      高岡直央、高山達也、宮崎美紀、藤田博美、譚成、大園誠一郎
    • Organizer
      第72回日本癌学会学術総会
  • [Presentation] TMAを用いた免疫染色の有用性の検討

    • Author(s)
      藤田博美、高山達也、高岡直央、譚成、宮崎美紀、甲斐文丈、杉山貴之、大園誠一郎
    • Organizer
      第72回日本癌学会学術総会
  • [Presentation] 腎細胞癌の全生存率におけるFABP7とBrn2の発現に性差が影響する

    • Author(s)
      譚成、高山達也、高岡直央、藤田博美、宮崎美紀、杉山貴之、甲斐文丈、大園誠一郎
    • Organizer
      第72回日本癌学会学術総会
  • [Presentation] 腎癌細胞株TUHR14TKBでの脳型脂肪酸結合タンパク質FABP7の機能解析

    • Author(s)
      高岡直央、高山達也、宮崎美紀、藤田博美、寺谷工、大園誠一郎
    • Organizer
      第22回泌尿器科分子・細胞研究会
  • [Presentation] FABP7とBrn2の発現の組み合わせは、腎癌の新たな予後予測因子である

    • Author(s)
      譚成、高山達也、高岡直央、藤田博美、宮崎美紀、甲斐文丈、杉山貴之、麦谷荘一、大園誠一郎
    • Organizer
      第71回日本癌学会学術総会
  • [Presentation] Docosahexaenoic Acid Inhibits Cell Growth of Renal Cell Carcinoma

    • Author(s)
      Takayama T, Zaima N, Takaoka N, Miyazaki M, Tan C, Sugiyama T, FuruseH, Mugiya S, Setou M, Ozono S
    • Organizer
      32nd Congress of the Société Internationale d'Urologie(SIU)
  • [Presentation] 腎癌で高発現するFABP7の腎癌細胞株での発現制御機構の解析

    • Author(s)
      高岡直央、高山達也、杉山貴之、甲斐文丈、寺谷工、宮崎美紀、藤田博美、麦谷荘一、大園誠一郎
    • Organizer
      第21回泌尿器科分子・細胞研究会
  • [Presentation] 腎癌細胞系での腎癌標識遺伝子脂肪酸結合蛋白質7の機能解析

    • Author(s)
      高岡直央、高山達也、杉山貴之、甲斐文丈、宮崎美紀、藤田博美、寺谷工、譚成、麦谷荘一、大園誠一郎
    • Organizer
      第70回日本癌学会学術総会
  • [Presentation] 腎細胞癌における脳型脂肪酸結合蛋白の発現

    • Author(s)
      譚成、高山達也、高岡直央、藤田博美、宮崎美紀、甲斐文丈、杉山貴之、麦谷荘一、大園誠一郎
    • Organizer
      第70回日本癌学会学術総会
  • [Book] 第4部臨床との連携I.腎癌の疫学、腫瘍病理鑑別診断アトラス「腎癌」2013

    • Author(s)
      大園誠一郞
    • Total Pages
      208-215
    • Publisher
      文光堂
  • [Book] 第III章分子標的薬の各論:1受容体・シグナル伝達系阻害薬(小分子化合物);3.mTOR阻害薬1)Everolimus、抗がん薬の臨床薬理2013

    • Author(s)
      大園誠一郎、杉山貴之
    • Total Pages
      487-490
    • Publisher
      南山堂
  • [Book] 第III章分子標的薬の各論:1受容体・シグナル伝達系阻害薬(小分子化合物);3.mTOR阻害薬2)Temsirolimus、抗がん薬の臨床薬理2013

    • Author(s)
      大園誠一郎、杉山貴之
    • Total Pages
      491-493
    • Publisher
      南山堂

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Published: 2015-07-16   Modified: 2015-07-29  

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