2013 Fiscal Year Final Research Report
Investigation on mucosa-derived substance that enhances spontaneous contractions of the urinary bladder in the rat with bladder outlet obstruction
| Project/Area Number |
23592359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Osamu 福井大学, 医学部, 教授 (90242552)
WATANABE Nozomu 福井大学, 医学部附属病院, 医員 (80572429)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 下部尿路閉塞 / 膀胱粘膜 / 膀胱自律収縮 / 生理学 / ストレス |
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| Research Abstract |
We examined what the mucosa-derived substance that can act to enhance spontaneous contractions (SCs) of the urinary bladder is in the rat with bladder outlet obstruction (BOO).
The SCs in bladder strips from BOO rats were associated with the amount of prostaglandin (PG) E2 released from the mucosa in vitro: The amount of PGE2 released from the mucosa was increased in BOO rats in vivo: The non-voiding contraction (NVC) that was regarded as a surrogate of SCs in the bladder wall in vivo was associated with mucosa-derived PGE2. The mucosa-derived substance to enhance SCs may be PGE2. We also found out that the presence of the intact nervous system innervating lower urinary tract and the up-regulation of the expression of cyclooxygenase-2 in the bladder wall were associated with the increased amount of PGE2 released from the mucosa induced by BOO.
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