2013 Fiscal Year Final Research Report
Expression and its functional role of Beta3-adrenoceptors in the human prostate
| Project/Area Number |
23592365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 前立腺 / β-アドレナリン受容体 / ヒト / β3-アドレナリン受容体 / 平滑筋 |
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| Research Abstract |
Expression of beta1-, beta2- and beta3-AR mRNA in the human prostate was confirmed by RT-PCR. On immunohistochemistry, positive staining for beta1-, beta2- and beta3-AR was identified not only in prostatic smooth muscles, but also glandular epithelium. In pharmacological study in vitro, a beta3-AR agonist concentration-dependently decreased KCL- or EFS-induced contraction of the human normal prostatic strips. In conclusion, beta3-AR agonists may have clinical benefit for lower urinary tract symptom due to either benign prostatic hyperplasia or neurogenic bladder.
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