Cross sectional study from gene and environmental factor towards

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: ITOH Yasunori 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (70295608)
• Co-Investigator(Kenkyū-buntansha): YASUI Takahiro 名古屋市立大学, 大学院医学研究科, 講師 (40326153) ; OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966) ; TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; KOHRI Kenjiro 名古屋市立大学, 大学院医学研究科, 教授 (30122047)
• Project Period (FY): 2011 – 2013
• Keywords: 尿路結石症 / メタボリックシンドローム / アディポサイトカイン / ストレス感受性シグナル / オステオポンチン / 結石モデルマウス / OPNノックアウトマウス / OPNトランスジェニックマウス

Research Abstract

Urolitiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and comared their results to patients background and stome composition.
We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NF kappa B as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.

Research Products

• [Journal Article] Oxygen nano-babble water reduces calcium oxalate deposits and tubular cell injury in ethylene glycol treated rat kidney (2013)
  • Author(s): Yasuhiko Hirose, Takahiro Yasui, Kazumi Taguchi, Yasuhiro Fujii, Kazuhiro Niim, Shuzo Hamamoto, Atsushi Okada, Yasue Kubota, Noriyasu Kawai, Yasunori Itoh, Keiichi Tozawa, Shoichi Sasaki, Kenjiro Kohri
  • Journal Title: Urolithiasis Volume: 41 Pages: 279-294
• [Journal Article] Efficacy of retroperitoneal laparoscopic ureterolithotomy for the treatment of large proximal ureteric stones and its impact on renal function (2013)
  • Author(s): Takahiro Yasui, Atsushi Okada, Shuzo Hamamoto, Kazumi Taguchi, Ryosuke Ando, Kentaro Mizuno, Yasunori Itoh, Keiichi Tozawa, Yutaro Hayashi, Kenjiro Kohri
  • Journal Title: Springerplus Volume: 2 Pages: 600
• [Journal Article] Mitocondrial permeability transition pore opening induces the initial process of renal calcium crystallization (2012)
  • Author(s): Niimi Kazuhiro, Yasui Takahiro, Hirose Masahito, Hamamoto Shuzo, Itoh Yasunori, Okada Atsushi, Kubota Yasue, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro
  • Journal Title: Free Radical Biology & Medicine Volume: 52 Pages: 1207-1217
• [Journal Article] Role of osteopontin in early phase of renal crystal formation : immunohistochemical and microstructural comparisons with osteopontin knock-out mice (2012)
  • Author(s): Hirose Masahito, Tozawa Keiichi, Okada Atsushi, Hamamoto Shuzo, Higashibata Yuji, Gao Bin, Hayashi Yutaro, Shimizu Hideo, Kubota Yasue, Yasui Takahiro, Kohri Kenjiro
  • Journal Title: Urological Research Volume: 40 Pages: 121-129
  • DOI: 10.1007/s00240-011-0400-z
• [Journal Article] Pioglitazone, a peroxisome proliferator activated receptorγagonist, decreases renal crystal deposition, oxidative stress and inflammation in hyperoxaluric rats (2012)
  • Author(s): Taguchi Kazumi, Okada Atsushi, Yasui Takahiro, Kobayashi Takahiro, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: Journal of Urology Volume: 188 Pages: 1002-1011
• [Journal Article] Biomolecular mechanism of urinary stone formation involving osteopontin (2012)
  • Author(s): Kohri Kenjiro, Yasui Takahiro, Okada Atsushi, Hirose Masahito, Hamamoto Shuzo, Fujii Yasuhiro, Niimi Kazuhiro, Taguchi Kazumi
  • Journal Title: Urological Research Volume: 40 Pages: 623-637
• [Journal Article] The role of long-term loading of cholesterol in renal crystal formation (2011)
  • Author(s): Itoh Yasunori, Yoshimura Mugi, Niimi Kazuhiro, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Okada Atsushi, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
  • Journal Title: Archivio Italiano di Urologia e Andrologia Volume: 83 Pages: 23-5
• [Journal Article] Efficacy of selectiveα1A adrenoceptor antagonist silodosin in the medical expulsive therapy for ureteral stones (2011)
  • Author(s): Itoh Yasunori, Okada Atsushi, Yasui Takahiro, Hamamoto Shuzo, Hirose Masahito, Kojima Yoshiyuki, Tozawa Keiichi, Sasaki Shoichi, Kohri Kenjiro
  • Journal Title: International Journal of Urology Volume: 18 Pages: 672-674
• [Journal Article] Effects of impaired functional domains of osteopontin on renal crystal formation : Analyses of OPN transgenic and OPN knockout mice (2011)
  • Author(s): Shuzo Hamamoto, Shintaro Nomura, Takahiro Yasui, Atsushi Okada, Masahito Hirose, Yasunori Itoh, Keiichi Tozawa, Kenjiro Kohri
  • Journal Title: J Bone Miner Res Volume: 26 Pages: 439
• [Presentation] Administration of the selective alpha 1A-adrenoceptor antagonist silodosin facilitates expulsion of size 5-10mm distal ureteral stones, as compared to control (2013)
  • Author(s): Itoh Yasunori, Okada Atsushi, Yasui Takahiro, Ryosuke Ando, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito,Fujita Keiji,Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 2nd Meeting of the EAU Section of Urolithiasis (EULIS)
  • Place of Presentation: Copenhagen(Denmark)
  • Year and Date: 20130905-07
• [Presentation] Administration of the selective alpha 1A adrenoceptor antagonist silodosin facilitates expulsion of 1.5mm or larger distal ureteral stones, as compared to control (2012)
  • Author(s): Yasunori Itoh, Atsushi Okada, Masahito Hirose, Shuzo Hamamoto, Takahiro Kobayashi, Kazuhiro Niimi, Yoshiyuki Kojima, Yasue Kubota, Takahiro Yasui, Keiichi Tozawa, Shoichi Sasaki, and Kenjiro Kohri
  • Organizer: AUA 2012 Annual Meeting
  • Place of Presentation: Atlanta(USA)
  • Year and Date: 20120520-25
• [Presentation] Efficacy of a selective alpha 1A adrenoceptor antagonist as a medical exclusive therapy against ureteral stones (2011)
  • Author(s): Itoh Yasunori, Okada Atsushi, Yasui Takahiro, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Fujita Keiji, Tozawa Keiichi, Kohri Kenjiro
  • Organizer: 1^<st> Meeting of the EAU Section of Urolithiasis (EULIS)
  • Place of Presentation: London(United Kingdom)
  • Year and Date: 20110907-10