2013 Fiscal Year Final Research Report

Human chorionic gonadotropin mediated intercellular signalling in human endometrial epithelial cells at implantation site

Research Project

Project/Area Number	23592399
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Obstetrics and gynecology
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	TAMURA Naoaki 浜松医科大学, 医学部附属病院, 助教 (90402370)
Co-Investigator(Kenkyū-buntansha)	KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550) SUGIHARA Kazuhiro 浜松医科大学, 医学部, 准教授 (00265878)
Project Period (FY)	2011 – 2013
Keywords	着床 / ヒト絨毛性ゴナドトロピン / 子宮内膜上皮細胞 / トロフィニン
Research Abstract	Under hCG treatment, expression levels of trophinin was enhanced and MUC1 was decreased in Ishikawa cells, one of endometrial epithelial cell lines. These alternations were more remarkable under hCG and IL-1beta treatment. From the Microarray analysis, gene expression levels of ADM and KISS1R were decreased in Ishikawa cells under hCG treatment.Genetic splicing variants of trophinin existed in Ishikawa cells. This fact suggested that trophinin may coordinate its function by dominant negative manner in vivo.