2013 Fiscal Year Final Research Report
elucidate a role of the meconium in the fatal cause of the amniotic fluid embolism
| Project/Area Number |
23592410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
OI Hidekazu 奈良県立医科大学, 医学部, 准教授 (10283368)
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| Co-Investigator(Kenkyū-buntansha) |
小林 浩 奈良県立医科大学, 医学部, 教授 (40178330)
野口 武俊 奈良県立医科大学, 医学部, 助教 (10464661)
常見 泰平 奈良県立医科大学, 医学部, 助教 (20599831)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 羊水塞栓症 / 羊水 / 胎便 / 分娩後異常母体出血 / SCC / Sialyl Tn |
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| Research Abstract |
The case that serum level of STN and CEA which were contained rich in meconium rose to after delivery was considered as the case that a meconium ingredient entered into the maternal circulation. The correlation between the difference in serum level of these tumor markers at the peripartum period and APPH was investigated statistically. And the correlation of each values of STN, CEA, C3, C4, FDP-DD in maternal serum in two groups with turbid amniotic fluid and clear amniotic fluid and APPH was investigated also. The result of making a study for the correlation between the difference of each values in maternal serum at peripartum period and APPH was not proved statistically. But the correlation between turbid amniotic fluid and APPH was observed significantly (P<0.05). The possibilities were suggested that when a large amount of turbid AF entered into maternal circulation, APPH will be occurred. This phenomenon will lead to the poor prognosis in the patients with amniotic fluid embolism.
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