2013 Fiscal Year Final Research Report
Therapeutic strategy for peritoneal dissemination of ovarian cancer using dynamic phototherapy and clofibric acid
| Project/Area Number |
23592429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 光線力学的療法 / 卵巣癌 / 腹膜播種 / 5-アミノレブリン酸メチルエステル / プロトポルフィリンIX / ヘム合成・分解 |
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| Research Abstract |
This study aimed to investigate the reason why intracellular amount of protoporphyrin IX (PpIX) varies in ovarian cancer cells and the effect of Photodynamic therapy (PDT) on peritoneal carcinomatosa. 1) The amount of PpIX (microg/dl) was 67.7 in DISS cells and 22.4 in MCAS cells. 2) Expression of delta-ALA synthetic enzyme, heme oxygenase and biliverdin reductase B in MCAS increased more then 3 times compared with those in DISS. 3) The rats treated with a methyl ester of 5-aminolevulinic acid (Methyl-ALA)-PDT was significantly longer in survival than those of the control and debulking surgery (DS)-Methyl-ALA-PDT significantly prolonged survival compared with DS alone. These results suggest that PpIX is not accumulated in cells in which heme synthesis and resolution is active and that Methyl-ALA-PDT is promising in ovarian cancer treatment. The amount of PpIX in cells is important in PDT treatment.
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Author(s)
Yokoyama Y, Futagami M, Watanabe J, Sato N, Terada Y, Miura F, Sugiyama T, Takano T, Yaegashi N, Kojimahara T, Kurachi H, Nishiyama H, Fujimori K, Tase T, Mizunuma H
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Author(s)
Yokoyama Y, Futagami M, Fijimoto T, Terada Y, Takatori E, Sugiyama T, Otsuki T, Yaegashi N, Kojimahara T, Kurachi H, Nishiyama H, Fujimori K, Tase T, Mizunuma H
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Oncol Rep
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Pages: 79-84
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[Journal Article] Yolk sac tumor of the ovary: a retrospective multicenter study of 33 Japanese women by Tohoku Gynecologic Cancer Unit (TGCU)2013
Author(s)
Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sato N, Terada Y, Tase T, Yokoyama Y, Mizunuma H, Shoji T, Sugiyama T, Kurachi H
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Journal Title
Tohoku J Exp Med
Volume: 230
Pages: 211-217
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[Journal Article] Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma2012
Author(s)
Ayhan A, Mao TL, Seckin T, Wu CH, Guan B, Ogawa H, Futagami M, Mizukami H, Yokoyama Y, Kurman RJ, Shih IM
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Journal Title
Int J Gynecol Cancer
Volume: 22
Pages: 1310-1315
DOI
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