The establishment of the sensitivity criteria in in vitro chemosensitivity test for clinical application

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Tsukuba
• Principal Investigator: OKI Akinori 筑波大学, 医学医療系, 教授 (60334067)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Hiroyuki 筑波大学, 医学医療系, 教授 (40158415) ; MINAGUCHI Takeo 筑波大学, 医学医療系, 講師 (40372396)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 抗がん剤感受性検査 / 婦人科悪性腫瘍 / 化学療法感受性 / 完全奏効 / パクリタキセル

Outline of Final Research Achievements

Nine cell lines, established from Gynecologic cancer patients, treated with paclitaxel(PTX)), performed in vitro chemosensitivity test against Paclitaxel(PTX). As a result, three patients whose cell lines were not obtain 50% cell growth inhibition (I50) in in vitro, were diagnosed as not effective for chemotherapy with PTX. In constant, cases, which obtained I50, were judged effective as beyond SD status in RECIST creteria. In CR case, not only I50 but I90 were achieved and she got cured.
In conclusion, the achievement of I50 in vitro test might be a predict factor for the clinical result of the chemotherapy

Free Research Field

婦人科悪性腫瘍