2013 Fiscal Year Final Research Report
Establishment of cancer virotherapy and imaging system targeting cancer stem cells in gynecologic cancer.
| Project/Area Number |
23592439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KYO Satoru 金沢大学, 医学系, 准教 (50272969)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌幹細胞 / 末梢血中腫瘍細胞 / テロメラーゼ |
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| Research Abstract |
We have established telomerase-specific replication-selective adenoviruses (TRAD) which can replicate only in telomerase activated cells. In the present study, we assessed the effectiveness of TRAD to the candidates of cancer stem cells in gynecologic cancer.
We have also developed a detection system for circulating tumor cells (CTCs) using GFP expressing TRAD. CTCs were detected in 40% of patients with gynecological malignancies. There was no significant correlation between CTC counts and tumor types or known clinicopathological factors, such as clinical stage and histological type. The CTCs rapidly vanished after surgery or chemotherapy in most patients whose treatments were effective. In contrast, the persistence of CTCs even after treatments was tightly associated with poor response to the treatments (P<0.005).
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[Journal Article] Circulating tumor cells detected by a novel adenovirus-mediated system may be a potent therapeutic marker in gynaecological cancers2012
Author(s)
Takakura M, Kyo S, Nakamura M, Maida Y, Mizumoto Y, Bono Y, Zhang X, Hashimoto Y, Urata Y, Fujiwara T, Inoue M
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Journal Title
Br J Cancer
Volume: 107(3)
Pages: 448-54
Peer Reviewed
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