2013 Fiscal Year Final Research Report
Analysis of the gastric lesion of the uterine cervix
| Project/Area Number |
23592440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
HASHI Akihiko 山梨大学, 医学部附属病院, 准教授 (10208431)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 子宮頸部腺がん / 子宮頸部胃型形質 |
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| Research Abstract |
(Study1)Endocervial-type adenocarcinoma of the uterine cervix were examined.We performed immunohistochemistry and in situ hybridization(ISH) on sections of routinely processed. Immunoexpression of p53, HIK1083 and p16 were investigated manually. ISH was performed using a GenPoint Catalyzed Signal Amplication System(DAKO Japan). The gastric mucin (HIK1083 positive) expression group were more likely to have frequent p53 overexpression and rare HPV signals compared with nongastric mucin expression group. There were a significant difference in each group. There is a probability that the carcinogenesis of the gastric mucin expression group is different from that of nongastric mucin expression group.
(Study2)We have demonstrated gastric pyloric pattern of cell differentiation in LEGH by the expression of PDX-1 and TFF2. TFF2 is useful immunohistochemical markers for LEGH.
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[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix : a multicenter study of clinicopathology and magnetic resonance imaging findings2011
Author(s)
Akiko Takatsu, Tanri Shiozawa, Tsutomu Miyamoto, Kazuko Kurosawa, Hiroyasu Kashima, Tomoko Yamada, Tsunehisa Kaku, Yoshiki Mikami, Takako Kiyokawa, Hitoshi Tsuda, Keiko Ishii, Kaori Togashi, Takashi Koyama, Yasunari Fujinaga, Masumi Kadoya, Akihiko HASHI, Nobuyuki Susumu, Ikuo Konishi
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Journal Title
Int J Gynecol Cancer
Volume: 21(7)
Pages: 1287-1296
Peer Reviewed
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