2013 Fiscal Year Final Research Report
Analysis of the expression and function of Notch-related factors in endometrial carcinoma
| Project/Area Number |
23592442
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
TAKATSU Akiko 信州大学, 医学部附属病院, 助教 (90447730)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Akihisa 信州大学, 医学部附属病院, 特任研究員 (10547095)
SHIOZAWA Tanri 信州大学, 医学部, 教授 (20235493)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Notch シグナル / 子宮内膜癌 / Notch 阻害薬 / Notch1 / Notch3 / JAG1 / DLL4 |
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| Research Abstract |
The expression of Notch receptors (Notch1 and 3) and Notch ligands (JAG1 and DLL4) was examined immunohistochemically in 37 normal and 76 malignant endometrial tissue samples. For each section, immunohistochemical staining was scored using a positivity index (PI, full score; 200). The PIs for Notch1 (mean 90.4), Notch3 (mean 95.6), JAG1 (mean 95.5) and DLL4 (mean 88.2), were significantly higher in endometrial carcinoma than normal endometrium. Patients with tumours showing high expression of both Notch1 and JAG1 had a poor prognosis compared with those having double-negative carcinomas (P = 0.015). The addition of a Notch inhibitor, DAPT, did not inhibit proliferation, but decreased invasion and motility of endometrial carcinoma cell lines. In conclusion, the Notch1-JAG1 axis may enhance the invasive properties of endometrial carcinomas, whichsuggests the Notch pathway may be a promising target for the treatment of this malignancy.
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