Biological significance of HB-EGF targeted therapy under development for advanced ovarian cancer patients

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Fukuoka University
• Principal Investigator: MIYAMOTO Shingo 福岡大学, 医学部, 教授 (40209945)
• Project Period (FY): 2011 – 2013
• Keywords: 卵巣癌 / HB-EGF / DNAマイクロアレイ / 血管新生 / 脂質代謝

Research Abstract

The aim of this study was to investigate biological significance of HB-EGF targeted therapy under development for advanced ovarian cancer patients. We found HB-EGF had interaction with angiogenesis- and lipid metabolism-related gene and others to increase tumor growth and invasion, not only increase growth activity of cancer directly. These results contributed to create diagnostic method of sensitivity against HB-EGF targeted therapy.

Research Products

• [Journal Article] Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer (2013)
  • Author(s): Yotsumoto F, Tokunaga E, Oki E, Miyamoto S, et al
  • Journal Title: Mol Cancer Res Volume: 11(5) Pages: 506-517
  • DOI: 10.1158/1541-7786
  • Peer Reviewed
• [Journal Article] Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer (2012)
  • Author(s): Kasai N, Kobayashi K, Miyamoto S, et al
  • Journal Title: Am J Transl Res Volume: 4(4) Pages: 415-421
  • Peer Reviewed
• [Journal Article] HB-EGFを標的とした卵巣癌治療法の開発 (2012)
  • Author(s): 南星旭、四元房典、黒木政秀、宮本新吾
  • Journal Title: 産婦人科の実際 Volume: 61(2) Pages: 215-222
  • Peer Reviewed
• [Journal Article] A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells (2011)
  • Author(s): Miyamoto S, Iwamoto R, Furuya A, et al
  • Journal Title: Clin Cancer Res Volume: 17(21) Pages: 6733-6741
  • DOI: 10.1158/1078-0432.CCR-11-1029
  • Peer Reviewed
• [Journal Article] Assessment of HB-EGF levels in peritoneal fluid and serum of ovarian cancer patients using ELISA (2011)
  • Author(s): Hikita S, Yotsumoto F, Miyamoto S
  • Journal Title: Anticancer Res Volume: 31(7) Pages: 2553-2559
  • URL: http://ar.iiarjournals.org/content/31/7/2553.long
  • Peer Reviewed
• [Presentation] Study on serum HB-EGF as a prognostic biomarker in ovarian cancer patients (2013)
  • Author(s): Miyata K, Yotsumoto F, Nam SO, Yagi H, Kobayashi H, Fumihiko S, Otsuki T, Kato K, Yaegashi N, Kuroki M, Miyamoto S
  • Organizer: 第72回日本癌学会学術集会総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-05
• [Presentation] micro RNA arrayを用いたHB-EGF標的治療反応性の血中マーカーの検索 (2013)
  • Author(s): 宮田康平、南星旭、四元房典、黒木政秀、目加田英輔、宮本新吾
  • Organizer: 第12回日本婦人科がん分子標的研究会学術集会
  • Place of Presentation: 奈良
  • Year and Date: 20130705-06
• [Presentation] 卵巣癌における化学療法反応性予測バイオマーカーとしてのheparin-binding epidermal growth factor-like growth factorの意義 (2013)
  • Author(s): 勝田隆博、四元房典、植田多恵子、前原都、近藤晴彦、八木裕史、小林裕明、高野忠夫、大槻健郎、加藤聖子、八重樫伸生、宮本新吾:
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 20130510-12
• [Presentation] CD36による卵巣癌標的分子heparin-binding epidermal growth factor-like growth factorの発現制御機構 (2013)
  • Author(s): 宮田康平、四元房典、南星旭、宮本新吾
  • Organizer: 第65回日本産科婦人科学会学術講演会
  • Place of Presentation: 札幌
  • Year and Date: 20130510-12
• [Presentation] HB-EGF特異的抑制剤CRM197腹腔内投与の抗腫瘍効果の検討 (2013)
  • Author(s): 南星旭、四元房典、宮田康平、黒木政秀、宮本新吾
  • Organizer: 第17回バイオ治療法研究会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2013-12-07
• [Presentation] 脂質代謝異常関連遺伝子による卵巣癌標的分子HB-EGFの発現制御機構 (2012)
  • Author(s): 南星旭、四元房典、宮田康平、山田博美、黒木政秀、宮本新吾:
  • Organizer: 第71回日本癌学会,札幌
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 塩酸イリノテカン療法に対する卵巣明細胞腺癌の耐性機構へのHB-EGFの関与とその発現機構の解明 (2012)
  • Author(s): 宮田康平、四元房典、南星旭、板持広明、紀川純三、宮本新吾
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
  • Year and Date: 20120413-15
• [Presentation] 脂質代謝異常関連遺伝子による卵巣癌標的分子heparin-binding epidermal growth factor-like growth factor(HB)の発現制御機構。 (2012)
  • Author(s): 南星旭、四元房典、宮田康平、宮本新吾
  • Organizer: 第64回日本産科婦人科学会学術講演
  • Place of Presentation: 神戸
  • Year and Date: 20120413-15
• [Presentation] Regulation of HB-EGF expression by transcriptional mechanism contributes to chemoresistance of ovarian clear cell carcinoma (2011)
  • Author(s): Miyata K, Yotsumoto F, Nam SO, Itamochi H, Kigawa J, M. Kuroki M, Miyamoto S
  • Organizer: International Society of Oncology and BioMarker 2011 Annual Meeting
  • Place of Presentation: Firenze, Italy
  • Year and Date: 20111015-19
• [Presentation] HB-EGF regulaltes angiogenesis-related molecules in mammary tumorigenesis (2011)
  • Author(s): Nam SO, Yotsumoto F, Miyata K, Tokunaga E, Akiyoshi S, Oki E, Kuroki M, Miyamoto
  • Organizer: International Society of Oncology and BioMarker 2011 Annual Meeting
  • Place of Presentation: Firenze, Italy
  • Year and Date: 20111015-19
• [Presentation] 乳癌の造腫瘍能に寄与する血管新生関連分子のヒエラルキー (2011)
  • Author(s): 南星旭、四元房典、宮田康平、徳永えり子、秋吉清百合、沖英次、前原喜彦、黒木政秀、宮本新吾
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 20111003-05
• [Presentation] がん標的治療薬の開発～HB-EGFを標的とした卵巣癌治療薬の開発を目指して～ (2011)
  • Author(s): 宮本新吾
  • Organizer: 第17回癌治療増感研究会
  • Place of Presentation: 仙台
  • Year and Date: 20110624-25